55° 48′ 0″ North, 38° 27′ 0″ East
Distance (in kilometers) between Elektrostal and the biggest cities of Russia.
Locate simply the city of Elektrostal through the card, map and satellite image of the city.
Weather forecast for the next coming days and current time of Elektrostal.
Find below the times of sunrise and sunset calculated 7 days to Elektrostal.
Day | Sunrise and sunset | Twilight | Nautical twilight | Astronomical twilight |
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8 June | 02:43 - 11:25 - 20:07 | 01:43 - 21:07 | 01:00 - 01:00 | 01:00 - 01:00 |
9 June | 02:42 - 11:25 - 20:08 | 01:42 - 21:08 | 01:00 - 01:00 | 01:00 - 01:00 |
10 June | 02:42 - 11:25 - 20:09 | 01:41 - 21:09 | 01:00 - 01:00 | 01:00 - 01:00 |
11 June | 02:41 - 11:25 - 20:10 | 01:41 - 21:10 | 01:00 - 01:00 | 01:00 - 01:00 |
12 June | 02:41 - 11:26 - 20:11 | 01:40 - 21:11 | 01:00 - 01:00 | 01:00 - 01:00 |
13 June | 02:40 - 11:26 - 20:11 | 01:40 - 21:12 | 01:00 - 01:00 | 01:00 - 01:00 |
14 June | 02:40 - 11:26 - 20:12 | 01:39 - 21:13 | 01:00 - 01:00 | 01:00 - 01:00 |
Our team has selected for you a list of hotel in Elektrostal classified by value for money. Book your hotel room at the best price.
Located next to Noginskoye Highway in Electrostal, Apelsin Hotel offers comfortable rooms with free Wi-Fi. Free parking is available. The elegant rooms are air conditioned and feature a flat-screen satellite TV and fridge... | from | |
Located in the green area Yamskiye Woods, 5 km from Elektrostal city centre, this hotel features a sauna and a restaurant. It offers rooms with a kitchen... | from | |
Ekotel Bogorodsk Hotel is located in a picturesque park near Chernogolovsky Pond. It features an indoor swimming pool and a wellness centre. Free Wi-Fi and private parking are provided... | from | |
Surrounded by 420,000 m² of parkland and overlooking Kovershi Lake, this hotel outside Moscow offers spa and fitness facilities, and a private beach area with volleyball court and loungers... | from | |
Surrounded by green parklands, this hotel in the Moscow region features 2 restaurants, a bowling alley with bar, and several spa and fitness facilities. Moscow Ring Road is 17 km away... | from | |
Below is a list of activities and point of interest in Elektrostal and its surroundings.
Direct link | |
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DB-City.com | Elektrostal /5 (2021-10-07 13:22:50) |
Pc playstation 3 xbox 360.
12 years ago#2 |
Written by Lanette Mayes
Modified & Updated: 01 Jun 2024
Reviewed by Jessica Corbett
Elektrostal is a vibrant city located in the Moscow Oblast region of Russia. With a rich history, stunning architecture, and a thriving community, Elektrostal is a city that has much to offer. Whether you are a history buff, nature enthusiast, or simply curious about different cultures, Elektrostal is sure to captivate you.
This article will provide you with 40 fascinating facts about Elektrostal, giving you a better understanding of why this city is worth exploring. From its origins as an industrial hub to its modern-day charm, we will delve into the various aspects that make Elektrostal a unique and must-visit destination.
So, join us as we uncover the hidden treasures of Elektrostal and discover what makes this city a true gem in the heart of Russia.
Elektrostal, a city located in the Moscow Oblast region of Russia, earned the nickname “Motor City” due to its significant involvement in the automotive industry.
Elektrostal is renowned for its metallurgical plant, which has been producing high-quality steel and alloys since its establishment in 1916.
Elektrostal has a long history of industrial development, contributing to the growth and progress of the region.
The city of Elektrostal was founded in 1916 as a result of the construction of the Elektrostal Metallurgical Plant.
Elektrostal is situated in close proximity to the Russian capital, making it easily accessible for both residents and visitors.
Elektrostal is home to several cultural institutions, including museums, theaters, and art galleries that showcase the city’s rich artistic heritage.
Surrounded by picturesque landscapes and forests, Elektrostal offers ample opportunities for outdoor activities such as hiking, camping, and birdwatching.
Every year, Elektrostal organizes festive events and activities to celebrate its founding, bringing together residents and visitors in a spirit of unity and joy.
Elektrostal is home to a diverse and vibrant community of around 160,000 residents, contributing to its dynamic atmosphere.
The city is known for its well-established educational institutions, providing quality education to students of all ages.
Elektrostal serves as an important hub for scientific research, particularly in the fields of metallurgy , materials science, and engineering.
The city is blessed with numerous beautiful lakes , offering scenic views and recreational opportunities for locals and visitors alike.
Elektrostal benefits from an efficient transportation network, including highways, railways, and public transportation options, ensuring convenient travel within and beyond the city.
Food enthusiasts can indulge in authentic Russian dishes at numerous restaurants and cafes scattered throughout Elektrostal.
Elektrostal boasts impressive architecture, including the Church of the Transfiguration of the Lord and the Elektrostal Palace of Culture.
Residents and visitors can enjoy various recreational activities, such as sports complexes, swimming pools, and fitness centers, enhancing the overall quality of life.
Elektrostal is equipped with modern medical facilities, ensuring residents have access to quality healthcare services.
The Elektrostal History Museum showcases the city’s fascinating past through exhibitions and displays.
Elektrostal is passionate about sports, with numerous stadiums, arenas, and sports clubs offering opportunities for athletes and spectators.
Throughout the year, Elektrostal hosts a variety of cultural festivals, celebrating different ethnicities, traditions, and art forms.
Elektrostal owes its name and initial growth to the establishment of electric power stations and the utilization of electricity in the industrial sector.
The city’s strong industrial base, coupled with its strategic location near Moscow, has contributed to Elektrostal’s prosperous economic status.
The Elektrostal Drama Theater is a cultural centerpiece, attracting theater enthusiasts from far and wide.
Elektrostal’s proximity to ski resorts and winter sport facilities makes it a favorite destination for skiing, snowboarding, and other winter activities.
Elektrostal prioritizes environmental protection and sustainability, implementing initiatives to reduce pollution and preserve natural resources.
Elektrostal is known for its prestigious schools and universities, offering a wide range of academic programs to students.
The city values its cultural heritage and takes active steps to preserve and promote traditional customs, crafts, and arts.
The Elektrostal International Film Festival attracts filmmakers and cinema enthusiasts from around the world, showcasing a diverse range of films.
Elektrostal supports aspiring entrepreneurs and fosters a culture of innovation, providing opportunities for startups and business development .
Elektrostal provides diverse housing options, including apartments, houses, and residential complexes, catering to different lifestyles and budgets.
Elektrostal is proud of its sports legacy , with several successful sports teams competing at regional and national levels.
Residents and visitors can enjoy a lively nightlife in Elektrostal, with numerous bars, clubs, and entertainment venues.
Elektrostal actively engages in international partnerships, cultural exchanges, and diplomatic collaborations to foster global connections.
Nearby nature reserves, such as the Barybino Forest and Luchinskoye Lake, offer opportunities for nature enthusiasts to explore and appreciate the region’s biodiversity.
The city pays tribute to significant historical events through memorials, monuments, and exhibitions, ensuring the preservation of collective memory.
Elektrostal invests in sports infrastructure and programs to encourage youth participation, health, and physical fitness.
Throughout the year, Elektrostal celebrates its cultural diversity through festivals dedicated to music, dance, art, and theater.
The city’s scenic beauty, architectural landmarks, and natural surroundings make it a paradise for photographers.
The convenient train connection between Elektrostal and Moscow makes commuting between the two cities effortless.
Elektrostal continues to grow and develop, aiming to become a model city in terms of infrastructure, sustainability, and quality of life for its residents.
In conclusion, Elektrostal is a fascinating city with a rich history and a vibrant present. From its origins as a center of steel production to its modern-day status as a hub for education and industry, Elektrostal has plenty to offer both residents and visitors. With its beautiful parks, cultural attractions, and proximity to Moscow, there is no shortage of things to see and do in this dynamic city. Whether you’re interested in exploring its historical landmarks, enjoying outdoor activities, or immersing yourself in the local culture, Elektrostal has something for everyone. So, next time you find yourself in the Moscow region, don’t miss the opportunity to discover the hidden gems of Elektrostal.
Q: What is the population of Elektrostal?
A: As of the latest data, the population of Elektrostal is approximately XXXX.
Q: How far is Elektrostal from Moscow?
A: Elektrostal is located approximately XX kilometers away from Moscow.
Q: Are there any famous landmarks in Elektrostal?
A: Yes, Elektrostal is home to several notable landmarks, including XXXX and XXXX.
Q: What industries are prominent in Elektrostal?
A: Elektrostal is known for its steel production industry and is also a center for engineering and manufacturing.
Q: Are there any universities or educational institutions in Elektrostal?
A: Yes, Elektrostal is home to XXXX University and several other educational institutions.
Q: What are some popular outdoor activities in Elektrostal?
A: Elektrostal offers several outdoor activities, such as hiking, cycling, and picnicking in its beautiful parks.
Q: Is Elektrostal well-connected in terms of transportation?
A: Yes, Elektrostal has good transportation links, including trains and buses, making it easily accessible from nearby cities.
Q: Are there any annual events or festivals in Elektrostal?
A: Yes, Elektrostal hosts various events and festivals throughout the year, including XXXX and XXXX.
Elektrostal's fascinating history, vibrant culture, and promising future make it a city worth exploring. For more captivating facts about cities around the world, discover the unique characteristics that define each city . Uncover the hidden gems of Moscow Oblast through our in-depth look at Kolomna. Lastly, dive into the rich industrial heritage of Teesside, a thriving industrial center with its own story to tell.
Our commitment to delivering trustworthy and engaging content is at the heart of what we do. Each fact on our site is contributed by real users like you, bringing a wealth of diverse insights and information. To ensure the highest standards of accuracy and reliability, our dedicated editors meticulously review each submission. This process guarantees that the facts we share are not only fascinating but also credible. Trust in our commitment to quality and authenticity as you explore and learn with us.
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The Pew-Knight Initiative supports new research on how Americans absorb civic information, form beliefs and identities, and engage in their communities.
Pew Research Center is a nonpartisan, nonadvocacy fact tank that informs the public about the issues, attitudes and trends shaping the world. Knight Foundation is a social investor committed to supporting informed and engaged communities. Learn more >
Pew Research Center conducted this study to understand how TikTok users, X (formerly Twitter) users, Instagram users and Facebook users experience news on these platforms. For this analysis, we surveyed 10,287 adult internet users in the United States from March 18 to 24, 2024.
Everyone who took part in the survey is a member of the Center’s American Trends Panel (ATP), an online survey panel that is recruited through national, random sampling of residential addresses. This way, nearly all U.S. adults have a chance of selection. The survey was weighted by combining the sample of internet users with data from ATP members who do not use the internet, and weighting the combined dataset to be representative of all U.S. adults by gender, race, ethnicity, partisan affiliation, education and other categories. The analysis in this report is based on those who use the platforms of interest. For more about how this was done, refer to the survey methodology . Read more about the ATP’s methodology .
Here are the questions used for this report , along with responses, and the survey methodology .
This is a Pew Research Center report from the Pew-Knight Initiative, a research program funded jointly by The Pew Charitable Trusts and the John S. and James L. Knight Foundation. Find related reports online at https://www.pewresearch.org/pew-knight/ .
Social media platforms are an important part of the American news diet: Half of U.S. adults say they get news at least sometimes from social media in general. But specific platforms differ widely in structure, content and culture. A new Pew Research Center survey finds that the ways in which Americans encounter news on four major platforms – TikTok, X, Facebook and Instagram – vary widely.
Key findings from this study include:
This project was designed to understand how people’s experiences and views differ across social media sites and apps .
The survey covered four social media platforms : TikTok, X (formerly Twitter), Facebook and Instagram. Each platform’s questions were identical.
This report focuses on news on social media. To learn about how people engage with politics on these platforms, read the companion report .
These are some of the key findings from a new Pew Research Center survey of about 10,000 U.S. adults conducted in March 2024. This is one of two Pew Research Center reports on habits and attitudes on different social media platforms from the Pew-Knight Initiative, a research program funded jointly by The Pew Charitable Trusts and the John S. and James L. Knight Foundation.
The rest of this overview looks at these patterns and other comparisons of the four platforms in more detail. For a closer look at individual platforms, jump to chapters on TikTok , X (formerly Twitter) , Facebook and Instagram .
News consumption is more common on some sites than others. A 2023 Pew Research Center survey found that Facebook outpaces all other social media sites as a news source for Americans, with 30% of U.S. adults saying they regularly get news there. Smaller shares regularly get news on Instagram (16%), TikTok (14%) or X (12%).
Some sites are more widely used in general than others. But there also are differences among users in the share who say they regularly get news on each site. According to a new Center survey, half of X users say they regularly get news there, compared with smaller shares on TikTok (40%), Facebook (37%) and Instagram (30%).
The new survey also asked users of each platform whether keeping up with the news is a major or minor reason they use the platform – or not a reason at all. X is the only platform on which a majority of users say that getting news is a reason they use it: Roughly two-thirds of X users (65%) say this is the case, including 25% who say keeping up with the news is a major reason they use X.
Fewer than half of TikTok, Facebook and Instagram users say that getting news is a major or minor reason they use the site. And just 15% of TikTok users, 7% of Facebook users and 8% of Instagram users say it’s a major reason.
People more frequently cite other reasons for using each platform. To read more about other reasons given for using each platform, read “How Americans Navigate Politics on TikTok, X, Facebook & Instagram.”
While a relatively small portion of users on these platforms say that getting news is a major reason they use them, far more on all platforms say they see news-related content there.
Opinions and humorous content related to news are common on all four platforms. Two-thirds or more of users on each site say they ever see people expressing opinions about current events or funny posts that reference current events. On Facebook, Instagram and TikTok, users are less likely to say they ever see news articles (whether posted, reposted, linked or screenshotted) or information about a breaking news event as it is happening. X is the only platform studied where at least three-quarters of users see all of these types of information.
Considering the four different types of news-related content asked about, a large majority of users on all the platforms say they ever see at least one of them. About eight-in-ten Instagram users see at least one of these types of news-related content (82%), as do 90% of TikTok users, 91% of Facebook users and 92% of X users.
X stands out as a place to see breaking news: 75% of users say they see information about breaking news in real time there, compared with smaller shares of users on Facebook (58%), TikTok (55%) and Instagram (44%).
X and Facebook users are the most likely to see news articles on each platform, with 79% of X users and 74% of Facebook users saying they do. Americans who use TikTok (57%) and Instagram (52%) are less likely to report seeing news articles.
Across sites, younger users are much more likely to see information about breaking news. On Instagram, for example, about half of users under 50 say they see breaking news about events as they’re happening (51%), compared with 29% of those 50 and older. And on X, where majorities of both age groups see breaking news on the platform, younger users are still more likely to than older users to see this (79% of users under 50 vs. 69% of those 50 and older).
Many questions on this survey were asked only of users who say they regularly get news on each site. The remainder of this overview looks through this lens to compare the experiences and opinions of these news consumers on TikTok, X, Facebook and Instagram.
Among those who regularly get news on each platform – also described as “news consumers” – the types of sources they get that news from differ from platform to platform.
Facebook news consumers are the most likely to say they’ve ever gotten news there from friends, family and acquaintances (85%). Most Instagram news consumers (72%) also say they have done this; friends and family are the most common news source for news consumers on both Facebook and Instagram. Americans who say they regularly get news on TikTok (48%) and X (26%) are much less likely to say they have gotten news there from friends, family and acquaintances. This is by far the least common source of information for X news consumers among the types of sources measured in the survey.
Majorities of news consumers report getting news from news outlets or journalists on all four sites. X news consumers are the most likely to say this (80%), compared with about two-thirds of news consumers on Facebook (68%), TikTok (67%) and Instagram (65%) who say the same.
TikTok news consumers are more likely than those on other platforms to say they get news from influencers and celebrities, with about two-thirds (68%) saying they ever do this. A majority of those who regularly get news on Instagram (59%) say the same.
There are only modest differences across the platforms in the share who get news from advocacy or nonprofit organizations: Around half on each site say they do.
While over half of news consumers on all four sites say they ever get news from other people they don’t know personally (beyond those previously mentioned), those on TikTok (84%) and X (75%) are especially likely to say this. For TikTok news consumers, these types of accounts are the most common news source.
Some of these sources are more likely to be used by different groups regardless of what platform they are using. For example, Democratic news consumers on most sites are more likely than their Republican counterparts to get news from advocacy or nonprofit organizations.
Amid broader concerns about the accuracy of information on social media , most news consumers on each of the four major social media platforms studied say they at least sometimes see news on the platform that seems inaccurate. This includes roughly a quarter or more on each site who say they extremely or fairly often see inaccurate news.
News consumers on X (37%) and Facebook (33%) are the most likely to say they often see news that seems inaccurate.
Americans also largely see social media platforms as influencing which news stories they see there to at least some extent.
About three-quarters of news consumers on Facebook (74%) and Instagram (72%) – both owned by Meta – say the platforms influence which news stories they see there at least some, including roughly three-in-ten who say the platforms have a lot of influence. On these sites, news consumers with a higher level of educational attainment are more likely to say the platforms influence which news stories they see.
Roughly two-thirds of X news consumers (66%) and 61% of TikTok news consumers say the sites influence what they are seeing at least somewhat.
Although users maintain some level of control by deciding whom they follow on each site, computer algorithms also impact users’ feeds on many social media platforms, and technology companies have a variety of policies on how they moderate content such as false information and violent imagery . Some sites allow users to modify their settings , though previous Center research has found that very few Americans feel like they have a lot of control over what they see online .
There are notable party divides in views toward the information on some platforms. Democrats who get news on X (including those who lean Democratic) are more likely than their Republican and GOP-leaning counterparts to say they extremely or fairly often see inaccurate news there (42% vs. 31%).
Democratic news consumers on X also are far more likely than their Republican counterparts to say X influences which news stories they see at least some (80% vs. 55%).
On Facebook, the reverse is true, with 38% of Republican Facebook news consumers saying they often see inaccurate news, compared with 29% of Democratic Facebook news consumers. Republican news consumers on Facebook also are more likely than Democratic news consumers on the site to say they think Facebook influences which news stories they see there at least some (80% vs. 68%).
There is little to no partisan difference in views toward Instagram and TikTok by these two measures.
The survey asked Americans who say they regularly get news on each site whether they think the news they get there is mostly news they would have gotten elsewhere, or whether it’s news they only would have found on that site.
News consumers on TikTok (35%) and X (29%) are the most likely to say that the news they get on those sites is unique – i.e., news they would not have seen elsewhere.
Smaller shares of news consumers on Instagram (21%) and Facebook (14%) hold this view. It’s more common for Instagram and Facebook news consumers to say that the news they see is mostly news they would have gotten elsewhere (34% and 36%, respectively).
On each of the four sites, about four-in-ten or more news consumers say that the news they see is an even mix of news they would have gotten elsewhere and news they would not have gotten elsewhere.
More than half of news consumers on three of the four sites studied at least sometimes feel worn out by the amount of news they see on these sites. This includes roughly one-in-five news consumers on Facebook (23%), X (20%) and Instagram (17%) who say they extremely or fairly often feel this way.
TikTok news consumers are somewhat less likely to often (11%) or sometimes (36%) feel worn out by the news they see on TikTok.
Democrats who regularly get news on X report often feeling worn out by the news there at a much higher rate than Republican news consumers on the platform (31% vs. 11%).
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National Institutes of Health ( NIH )
P50 Specialized Center
See Section III. 3. Additional Information on Eligibility .
This Notice of Funding Opportunity (NOFO) invites applications for centers to support transdisciplinary teams of clinical and mental health services researchers, behavioral scientists, social scientists, health information and communications technologists, health systems engineers, decision scientists, and mental health stakeholders (e.g., service users, family members, clinicians, payers) to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States. A dvanced L aboratories for A ccelerating the R each and I mpact of T reatments for Y outh and Adults with Mental Illness (ALACRITY) Research Centers will support the rapid development, testing, and refinement of novel and integrative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders within well-defined target populations; (2) organizing and delivering optimized mental health services within real world treatment settings; and (3) continuously improving the quality, impact, and durability of optimized interventions and service delivery within various care systems that provide mental health interventions and services. The ALACRITY Centers program is intended to support research that maximizes synergies across various components of the mental health research ecosystem, including new discoveries in clinical research, transformative health care technologies, advances in information science, and new federal and state mechanisms for organizing mental health care. The Centers are intended for transdisciplinary projects that could not be achieved using standard research project grant mechanisms. The ALACRITY Centers program is also expected to facilitate widespread sharing of relevant data, methods, and resources that will accelerate clinical research and practice and provide opportunities for graduate students, postdoctoral researchers, and early-career investigators to participate in transdisciplinary, T2 translational mental health research.
30 days prior to the application due date.
Application Due Dates | Review and Award Cycles | ||||
---|---|---|---|---|---|
New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
May 17, 2024 | May 17, 2024 | Not Applicable | November 2024 | January 2025 | April 2025 |
May 19, 2025 | May 19, 2025 | Not Applicable | November 2025 | January 2026 | April 2026 |
May 18, 2026 | May 18, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
All applications are due by 5:00 PM local time of applicant organization.
Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.
Not Applicable
It is critical that applicants follow the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.
Section i. notice of funding opportunity description.
Purpose
This Notice of Funding Opportunity (NOFO) invites applications for center grants to support A dvanced L aboratories for A ccelerating the R each and I mpact of T reatments for Y outh and Adults with Mental Illness (ALACRITY) Centers. The purpose of these research Centers is to support transdisciplinary teams of clinical and mental health services researchers, behavioral scientists, social scientists, health information and communications technologists, health systems engineers, decision scientists, and mental health stakeholders (e.g., service users, family members, clinicians, payers) to engage in high-impact studies that will significantly advance clinical practice and generate knowledge that will fuel transformation of mental health care in the United States. Successful ALACRITY Centers will address major mental health problems observed among children, youth, and/or adults (including older adults), and foster innovative research aimed at increasing the effectiveness of existing interventions, improving delivery and quality of evidence-based services, and accelerating the diffusion, implementation, and continuous improvement of new practices in a broad array of settings that deliver mental health interventions and services. Center-supported research should reflect a deployment-focused model of intervention and services design and testing that considers key characteristics of the settings and providers where optimized mental health interventions and services will be implemented.
The ALACRITY Centers program is intended to support research that maximizes synergies across disciplines and has a high potential for increasing the public health impact of existing and emerging mental health interventions and service delivery strategies. The Centers are intended for transdisciplinary projects that could not be achieved using standard research project grant mechanisms. Support is provided both for individual research projects and for cores that are critical for the integration across ALACRITY components. Centers are expected to provide plans for rapid, widespread sharing of relevant data, methods, and resources that will promote near-term improvements in clinical practice, as well as plans that further advance research focused on intervention effectiveness and/or services. A strong vision of how the ALACRITY Center will advance the field beyond the goals of the individual projects is essential for successful applications.
With ALACRITY Centers, NIMH encourages opportunities to enhance the participation of individuals from groups that are underrepresented in biomedical, clinical, behavioral, and social sciences to participate in interdisciplinary research (see NOT-OD-20-031 ), including graduate students, postdoctoral researchers, and investigators in early stages of independent careers.
Background
Based on data from the 2021 National Survey on Drug Use and Health (NSDUH), it is estimated that more than one in five U.S. adults live with a mental illness; in 2021, an estimated 57.8 million lived with a diagnosable illness in the past year . NSDUH results further suggest that in 2021, an estimated 11.4 million American adults suffered from a serious mental illness (SMI) where ability to function in daily life is significantly impaired. We know that mental disorders frequently onset before the age of 18; the National Comorbidity Survey Adolescent Supplement estimated the lifetime prevalence of any mental disorder among U.S. adolescents aged 13-18 at 49.5%, with an estimated 22.2% of adolescents with any mental disorder experiencing severe impairment and/or distress. These prevalent illnesses are associated with substantial disability and burden, and it has been documented that individuals with SMI die 10 years earlier than individuals in the general population, on average. Furthermore, mental illnesses are associated with substantial direct and indirect costs, including but not limited to lost employment, reduced worker productivity, homelessness and criminal justice costs. A conservative estimate places the direct and indirect financial costs associated with mental illnesses in the United States at well over $300 billion annually. At the same time, we know that mental illnesses often go untreated. For example, according to 2021 NSDUH results, over half of adults with any mental illness and a third of those with SMI reported they did not receive MH services in the past year. This public health burden and unmet need demands that we combine current knowledge about effective mental disorder treatments with emerging health information and communication technologies, health care informatics, data science tools, and novel organizational structures for delivering health care to achieve significantly better outcomes for these disabling conditions.
Scope of Research
The primary purpose of each ALACRITY Center is to support rapid development, testing, and refinement of innovative approaches for (1) optimizing the effectiveness of therapeutic or preventive interventions for mental disorders within well-defined target populations; (2) organizing and delivering optimized mental health services within real world treatment settings; and (3) continuously improving the quality, impact, and sustainability of optimized interventions and service delivery strategies within various care systems that provide mental health interventions and services. To achieve these ambitious goals, each ALACRITY Center aims to support multidisciplinary teams of leading clinical and mental health services researchers, and experts from allied disciplines, such as behavioral scientists, social scientists, health information and communications technologists, health systems engineers, decision scientists, and mental health stakeholders (e.g., service users, family members, clinicians, payers) to engage in studies focused on selected populations for whom existing interventions or services do not adequately address urgent, unmet mental health needs.
The NIMH Strategic Plan for Research was developed to inspire and support research that takes advantage of recent technological advances and opportunities, and to bring into sharper focus questions and perspectives that will transform the diagnosis, treatment, and prevention of mental disorders. Strategic Research Objectives 3.2, 3.3, and 4.1 – 4.4, which focus on optimizing existing and new interventions, translating effective interventions to community practice settings, and strengthening the public health impact of NIMH-supported research, are particularly relevant to ALACRITY Centers. ALACRITY Centers provide a unique opportunity for addressing T2 translational priorities outlined in the NIMH Strategic Plan, i.e., effective transfer of findings from clinical studies to practice settings and communities, where research findings can be applied to improve public health.
General characteristics of ALACRITY Centers are listed below:
Potential applicants are strongly encouraged to discuss their research concept and approach, and alignment of planned Center goals with the NIMH Strategic Plan for Research, with appropriate NIMH contacts before developing their application [see section VII Agency Contacts ].
The NIMH has published updated policies and guidance for investigators regarding human research protection and clinical research data and safety monitoring ( NOT-MH-19-027 ). The applications Protection of Human Subjects section should reflect the policies and guidance in this notice. Plans for the protection of research subjects and data and safety monitoring will be reviewed by the NIMH for consistency with NIMH and NIH policies and federal regulations.
See Section VIII. Other Information for award authorities and regulations.
Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs.
Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
Renewal of applications submitted in response to PAR-16-354 and PAR-18-701.
Resubmission of applications submitted in response to PAR-20-293 and PAR-23-210 .
Revisions of applications submitted in response to PAR-20-293 and PAR-23-210.
The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Optional: Accepting applications that either propose or do not propose clinical trial(s).
The total amount awarded and the number of awards are contingent upon NIH appropriations and will depend on the number, quality, and costs of meritorious applications received.
Direct costs are limited to $1,500,000 per year.
The total project period may not exceed 5 years.
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
1. Eligible Applicants
Higher Education Institutions
The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
Nonprofits Other Than Institutions of Higher Education
For-Profit Organizations
Local Governments
Federal Governments
Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement , are allowed.
Applicant organizations
Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.
Program Directors/Principal Investigators (PD(s)/PI(s))
All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from diverse backgrounds, including underrepresented racial and ethnic groups, individuals with disabilities, and women are always encouraged to apply for NIH support. See, Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities, NOT-OD-22-019 .
For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.
2. Cost Sharing
This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement .
3. Additional Information on Eligibility
Number of Applications
Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
The NIH will not accept duplicate or highly overlapping applications under review at the same time, per 2.3.7.4 Submission of Resubmission Application . This means that the NIH will not accept:
Renewal Eligibility
1. Requesting an Application Package
The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.
2. Content and Form of Application Submission
It is critical that applicants follow the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide , except where instructed in this notice of funding opportunity to do otherwise and where instructions in the Application Guide are directly related to the Grants.gov downloadable forms currently used with most NIH opportunities. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
By the date listed in Part 1. Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information:
The letter of intent should be sent to: [email protected]
Page Limitations
All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.
Component | Component Type for Submission | Page Limit | Required/Optional | Minimum | Maximum |
---|---|---|---|---|---|
Overall | Overall | 6 | Required | 1 | 1 |
Admin Core | Admin Core | 6 | Required | 1 | 1 |
Methods Core | Core | 12 | Required | 1 | 1 |
Signature Research Project | Signature Project | 12 | Required | 1 | 1 |
Exploratory Research Projects | Exploratory Project | 6 | Required | 3 | 3 |
Instructions for the Submission of Multi-Component Applications
The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing a multi-component application.
Revision applications must include an Overall component and the components that are affected by the revision. Therefore, the component requirements listed below may not apply to the revision application.
The application must consist of the following components:
Administrative Core
Methods Core
Overall Component
When preparing the application, use Component Type ‘Overall.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.
SF424(R&R) Cover (Overall)
Complete entire form.
PHS 398 Cover Page Supplement (Overall)
Note: Human Embryonic Stem Cell lines from other components should be repeated in cell line table in Overall component.
Research & Related Other Project Information (Overall)
Follow standard instructions.
Project/Performance Site Locations (Overall)
Enter primary site only.
A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.
Research and Related Senior/Key Person Profile (Overall)
Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application.
It is expected that a Center Director (PD/PI) will have a demonstrated capability to organize, administer, and direct the Center. The Center Director must demonstrate leadership in the area of the science proposed and have a strong record of high impact scientific achievements.
A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.
Budget (Overall)
The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover.
A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission.
PHS 398 Research Plan (Overall)
Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.
Specific Aims: Provide a concise description of the overall ALACRITY Center focus and aims. Outline how the research projects and Cores will contribute to attaining the Center objectives.
Research Strategy: All items listed below must be included.
Begin the Research Strategy with an overview of the Center describing the target population for whom existing interventions or services do not adequately address mental health needs, the therapeutic or preventive interventions or service delivery strategies to be studied and optimized, the service settings intended to implement optimized interventions and/or services, the integration of the ALACRITY Center components, and why these components are essential for accomplishing the goals of the overall Center. Target the overview description to a broad audience and be concise. The overview must include :
1. Goals, relevant background, significance and a description of the impact of the proposed research in relation to the state-of-the-art of the field. Include an explanation of how the work proposed is both innovative and potentially impactful for advancing clinical practice and clinical outcomes with members of the target population. Justify the focus of the ALACRITY Center in terms of the potential impact of research, vis- -vis the:
ALACRITY Centers may include technology development as an element, but not as the main focus of the Center. When technology development is an integral part of the scientific goals, it may be proposed as a project. When technology development is part of a standard service provided to support Center projects, it maybe proposed as an element of the Methods Core.
2. Value added by an interdisciplinary Centers approach. Address why the proposed research justifies a Center and include a description of the contribution of each of the projects and cores in achieving the Centers major objectives, a description of how the Center as a whole will benefit from interdisciplinary interactions, an explanation of why this work cannot be accomplished by a cluster of individual research project grants (e.g., R01s, R34s), and why the whole is significantly better than the sum of its parts. Describe how Center resources and Investigator support will be leveraged to create efficiencies within other projects beyond the Center-supported Signature and Exploratory research projects and 1-2 year pilot feasibility projects.
3. An explanation of the potential importance and relevance of the proposed research for increasing the effectiveness of existing interventions for a target population with unmet mental health needs, improving delivery and quality of optimized evidence-based services, and/or accelerating the diffusion, implementation, and continuous improvement of new practices in these settings. NIMH is particularly interested in programs of research that will lead to near-term improvements in clinical practice for mental disorders.
Address the following:
1. Preliminary Data : Include evidence for feasibility and preliminary findings. Present very clear evidence that the research team has been/will be able to work together effectively to accomplish the research proposed in the projects.
2. Center Approach : Describe the working scientific and logistical design, as well as the resource support necessary to implement the research. When multiple institutional sites are involved, include a detailed description of the cooperative administrative arrangements. (Include documentation of these arrangements in the Letters of Support section.)
Letters of Support: Include letters of support relevant to the overall center here. Letters detailing contributions to individual components are to be placed in their respective individual Research Project and Core components.
Resource Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide.
Consolidate and detail information regarding sharing of all Center-generated resources in this section and include the following elements as appropriate:
Other Plan(s):
Note: Effective for due dates on or after January 25, 2023, the Data Management and Sharing Plan will be attached in the Other Plan(s) attachment in FORMS-H application forms packages. If required, the Data Management and Sharing (DMS) Plan must be provided in the Overall component.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions:
To advance the goal of advancing research through widespread data sharing among researchers, investigators funded under this Notice of Funding Opportunity (NOFO) are expected to share those data via the National Institute of Mental Health Data Archive (NDA; see NOT-MH-23-100 ). Established by the NIH, NDA is a secure informatics platform for scientific collaboration and data-sharing that enables the effective communication of detailed research data, tools, and supporting documentation. NDA links data across research projects through its Global Unique Identifier (GUID) and Data Dictionary technology. Investigators funded under this NOFO are expected to use NDA technologies to submit data in accordance with the NDA Data Sharing Terms and Conditions , incorporated by reference. .
To accomplish this objective, it will be important to formulate a) an enrollment strategy that will obtain the information necessary to generate a GUID for each participant, and b) a budget strategy that will cover the costs of data submission. The NDA website provides two tools to help investigators develop appropriate strategies: 1) the NDA Data Submission Cost Model which offers a customizable Excel worksheet that includes tasks and hours for the Program Director/Principal Investigator and Data Manager to budget for data sharing; and 2) plain language text to be considered in your informed consent available from the NDA's Data Contribution page . Investigators are expected to certify the quality of all data generated by grants funded under this NOFO prior to submission to NDA and review their data for accuracy after submission. Submission of descriptive/raw data is expected semi-annually (every January 15 and July 15); submission of all other data is expected at the time of publication, or prior to the end of the grant, whichever occurs first (see NDA Sharing Regimen for more information); Investigators are expected to share results, positive and negative, specific to the cohorts and outcome measures studied. For more guidance on submitting data to NDA, refer to the NDA Data Sharing Plan on the NDA website. NDA staff will work with investigators to help them submit data types not yet defined in the NDA Data Dictionary .
Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide; any instructions provided here are in addition to the SF424 (R&R) Application Guide instructions.
PHS Human Subjects and Clinical Trials Information (Overall)
When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:
If you answered “Yes” to the question “Are Human Subjects Involved?” on the R&R Other Project Information form, there must be at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record within the application. The study record(s) must be included in the component(s) where the work is being done, unless the same study spans multiple components. To avoid the creation of duplicate study records, a single study record with sufficient information for all involved components must be included in the Overall component when the same study spans multiple components.
Study Record: PHS Human Subjects and Clinical Trials Information
All instructions in the SF424 (R&R) Application Guide must be followed.
Section 3 - Protection and Monitoring Plans
3.1 Protection of Human Subjects
Applications with data collection plans that involve multiple respondent groups (e.g., clients/patients, therapists/providers, supervisors, administrators) should address provisions for human subject protections and consenting procedures for all participant groups, accordingly.
Delayed Onset Study
Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the SF424 (R&R) Application Guide must be followed.
PHS Assignment Request Form (Overall)
When preparing your application, use Component Type ‘Admin Core.
All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions, as noted.
Note: Effective for due dates on or after January 25, 2023, the Data Management and Sharing Plan will be attached in the Other Plan(s) attachment in FORMS-H application forms packages. If required, the Data Management and Sharing (DMS) Plan must be provided in the Overall component.
Complete only the following fields:
Enter Human Embryonic Stem Cells in each relevant component.
Human Subjects: Answer only the ‘Are Human Subjects Involved? and 'Is the Project Exempt from Federal regulations? questions.
Vertebrate Animals: Answer only the 'Are Vertebrate Animals Used?' question.
Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.
List all performance sites that apply to the specific component.
Note: The Project Performance Site form allows up to 300 sites, prior to using additional attachment for additional entries.
Budget forms appropriate for the specific component will be included in the application package.
Each proposed Center Director must commit a minimum effort of 3 person months per year overall to the Center and be a leader of one of the projects and of the Administrative Core. The 3 person months should be a total of the Center Director's efforts on his/her project(s) and core(s). The 3 persons month requirement applies to each individual listed as a Center PD/PI in a multiple PD/PI Center.
The Leadership of the Administrative Core must commit a cumulative minimum effort of 1 person month per year to the Administrative Core. Multiple leaders are allowed for the Administrative Core. If there are multiple leaders for this Core, the combined effort of the identified Administrative Core Leaders must total at least 1 person month per year.
The Administrative Core budget should include costs for:
Note: The R&R Budget form included in many of the component types allows for up to 100 Senior/Key Persons in section A and 100 Equipment Items in section C prior to using attachments for additional entries. All other SF424 (R&R) instructions apply.
Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is allowed for each component.
The most commonly referenced Research Plan attachments are listed below for your convenience. NOFO–specific instructions are required for the Specific Aims and the Research Strategy in each component. NOFO-specific instructions are optional for Letters of Support. Delete Letters of Support if there are no NOFO-specific instructions.
Specific Aims: Provide a concise description of the goals of the Administrative Core
Research Strategy: The Administrative Core is expected to have appropriate and effective administrative and organizational capabilities to (a) facilitate innovative and nimble transdisciplinary T2 translational research in mental health, (b) foster synergy among research disciplines and cores, (c) oversee the solicitation, review, and selection of additional innovative pilot studies that capitalize on center resources and extend the research program, (d) support research opportunities for early stage investigators, (e) communicate the Centers aims and activities, (f) oversee evaluation activities, and (g) carry out future planning.
Highlight features of the Administrative Core that will enhance the collaborative effort, including optimizing communication, decision-making and sharing between the Research Projects and the Methods Core.
Describe how each Research Project and the Methods Core (as applicable) will draw upon the Administrative Core and how it in turn will respond to Research Project or Methods Core needs. The description of the Administrative Core should clearly indicate the facilities, resources, services and professional skills that the Core will provide. Moreover, information must be provided about how the collective operation of the Core will be affected in a coherent manner.
For each year of the award, the Administrative Core should include provisions for 2 or more pilot feasibility studies of 1-2 years duration that can be proposed by new or established investigators, including projects that are proposed by or involve post-doctoral researchers and early-stage investigators preparing for independent research careers. These pilot feasibility projects should be similar in purpose and scope to small research project grants (R03 ) and address innovative, interdisciplinary research consistent with the Center's focus. Pilot feasibility studies should serve as a mechanism for conducting nimble proof-of-concept studies (e.g., to rapidly refine/optimize intervention and service delivery approaches) that will position the investigator(s) for subsequent research that aligns with the Center's scientific goals. The application should detail a systematic approach for soliciting, reviewing, selecting, and monitoring the progress of the pilot studies. All pilot projects must comply with applicable NIH policies and the evidence that proposed plans for protection of human subjects; inclusion of women, minorities, and children; and assurance of animal welfare must be submitted to the NIMH Program Official prior to study initiation.
Additional information required in the Administrative Core Research Strategy:
Letters of Support: Include letters of support relevant to the Administrative Core (e.g., letters from stakeholders who will partner to inform research topics, conduct research, and help ensure the research has external validity and utility.)
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification:
Only limited items are allowed in the Appendix. Follow all instructions for the Appendix as described in the SF424 (R&R) Application Guide; any instructions provided here are in addition to the SF424 (R&R) Application Guide instructions.
When involving human subjects research, clinical research, and/or NIH-defined clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:
If you answered Yes to the question Are Human Subjects Involved? on the R&R Other Project Information form, you must include at least one human subjects study record using the Study Record: PHS Human Subjects and Clinical Trials Information form or a Delayed Onset Study record.
All instructions in the SF424 (R&R) Application Guide must be followed.
Note: Delayed onset does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the SF424 (R&R) Application Guide must be followed.
When preparing your application, use Component Type ‘Methods Core.
Phs 398 cover page supplement (methods core), research & related other project information (methods core).
Vertebrate Animals: Answer only the ‘Are Vertebrate Animals Used? question.
Research & related senior/key person profile (methods core).
The Leadership of the Methods Cores must commit a cumulative minimum effort of 3 person months per year to the Methods Core. Multiple leaders are allowed for Methods Cores. If there are multiple leaders for this core, the efforts of the identified leaders must total at least 3 person months per year.
Specific Aims: Provide a concise description of the goals of the Methods Core. Explain how the Methods Core will contribute to individual Research Projects and to attaining ALACRITY Center objectives.
Research Strategy: Describe how the Methods Core will function as an incubator for innovative approaches to optimizing and enhancing the effectiveness of interventions/service delivery models for selected mental disorders. Describe how the Methods Core will facilitate novel and convergent solutions to intractable mental health problems by integrating input from clinical and services researchers, insights from key mental health stakeholders, and contributions from experts in complementary fields, as relevant (e.g., behavioral and social science, health information and communications technology, health system engineering, decision science, bioinformatics, and/or data modeling). Describe how the Methods Core will stimulate additional research collaborations, identify future research directions, and ultimately boost the clinical impact, delivery, reach, and continuous improvement of mental health interventions. Detail how the Core's collective expertise will function to facilitate each of the following:
Development of Research Projects : Detail how the Methods Core will facilitate the development and design of the Center's Signatures and Exploratory Research Projects. Describe how the Core will identify and apply scientific, technological, and methodological innovations and tools to facilitate the research enterprise (e.g., identify opportunities to rapidly refine/optimize intervention content and delivery; apply innovative approaches to study design, participant selection/engagement, ecologically valid assessment, and monitoring of study progress). Describe how the Core's efforts will accelerate delivery of convergent interventions and services in clinical and community settings (e.g., identify and test novel applications of emerging technologies, information science, systems engineering, and other approaches that can be used to seamlessly integrate research-supported strategies into routine practice).
Operational Support to Research Projects : Describe how the Methods Core will provide expert conceptual, methodological, technical, and analytic statistical support to the Center's investigators. Describe the facilities and resources that will be available for conducting research projects of the Center, including (a) laboratories, research clinics, and/or community practice settings, (b) a Central Institutional Review Board (IRB), and (c) centralized clinical assessment and data management services. Present the plan for data collection, data quality assurance, and data management for Center projects presented in the Research Projects section, together with the plans for statistical analyses. If the research activities of the ALACRITY Center include clinical trials, describe the operational structures that will ensure good clinical practice as well as human subject protections.
Generate Innovative Research Methods : Detail how the Methods Core will function as an incubator for innovative new methods (e.g., novel assessment and data collection strategies; innovative study designs; new analytic strategies, including computational approaches for leveraging large, complex data). Describe how the Core will facilitate opportunities for embedding common data elements and for harmonizing data collection and analysis across Center projects.
Chart New Research Directions : Describe the Core's role in generating new research opportunities that capitalize on the Center's transdisciplinary nature. Detail the Core's role in catalyzing, selecting, and rapidly implementing pilot studies proposed by Center collaborators, including postdoctoral researchers, junior faculty, and new investigators, during the 5-year project period. Describe strategies that will be used to monitor and incorporate emerging scientific, technological, methodological, and analytic innovations and to identify and engage new collaborators working in allied areas, such as adult learning, machine learning, artificial intelligence, bioinformatics, etc. Describe how collaborative activities among Core investigators and stakeholders will culminate in future projects and grant applications that build off of the Signature Project and the three Exploratory Research Projects.
Dissemination of Methodological Advances and other Center-generated Resources : Describe how the Core will function as a national consultation resource beyond the Center collaborations. Detail the Core's role in facilitating the development and dissemination of research resources (e.g., new data collection/assessment approaches and analytic methods; web-based platforms for identifying and recruiting participants and accelerating research; data sets that can be shared for re-analysis/meta-analysis; other common-source materials (e.g., new methods and analytic strategies for mining and analyzing "big data" from large-scale data collection efforts, programming for technology-assisted approaches).
Evaluation of the Center's Research Productivity and Impact : Describe how methodological and analytic expertise within the Methods Core's will contribute to a comprehensive and valid evaluation of the Center's progress, including evaluation of the Center's:
Letters of Support: Include letters of support relevant to the Methods Core (e.g., letters from stakeholder who will partner to inform research topics, conduct research, and help ensure the research has external validity and utility).
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification: All information on the sharing of resources should be consolidated in the Administrative Core.
Signature research project.
When preparing your application, use Component Type ‘Signature Research Project.
Phs 398 cover page supplement (signature research project), research & related other project information (signature research project), project /performance site location(s) (signature research project), research & related senior/key person profile (signature research project).
The Project Lead(s) must commit a total minimum effort of 1.8 person months per year to each project. Multiple project leads are allowed for Projects. If there are multiple leads on a Project, the combined efforts of the identified project leads must total 1.8 person months per year. Do not include costs for staffing that are already included in the Administrative or Methods Cores.
Specific Aims: Provide a concise description of the aims the project.
Research Strategy: This section of the application can be organized with the headers below for ease and clarity of review.
Significance: Describe overall goals and the impact of the science proposed in the project in relation to the state-of-the-art of the field. Explain the contribution of the project to the overall goals of the Center, how the project will interact with and benefit from other components of the Center and the appropriateness of the center approach and environment.
Innovation: Describe the unique and innovative contributions that will be made by the research project. Explain how these contributions will synergize with the rest of the Center to achieve more than what could be achieved through an independent research project. Research projects should propose novel, transdisciplinary, convergent solutions to intractable mental health problems by integrating input from the experts brought together in the ALACRITY Center.
Approach: Signature research projects should constitute fully powered studies that address a significant problem that exemplifies the Centers focus.
Cite pilot data, from the investigator team's prior studies or from the extant literature to support well-justified hypotheses and the overall approach.
Justify the scale and scope of the study in terms of:
Describe how the Signature Project leverages the Center's infrastructure to efficiently conduct a large-scale project that will advance the Center's mission.
Signature Research Projects Involving Clinical Trials :
Signature Research Projects might involve effectiveness trials that are focused on testing effectiveness of 1) optimizing preventive and therapeutic interventions, for use with the target population(s) in the identified community practice settings, or 2) innovative services interventions that target patient-, provider-, or systems-level factors in order to improve care quality, coordination, delivery, or scalability of mental health services. The overall scope of research should be based on NIMH R01 research mechanisms for Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions ( PAR-21-130 ).
Other Signature Research Projects might include services research that is consistent with NIMH's Strategic Plan and the Centers focus, but is not focused on clinical trials that test services interventions. The overall scope of research should be based on NIMH R01 research mechanism for Innovative Mental Health Services Research Not Involving Clinical Trials ( PAR-23-095 ). Such research might seek to: 1) Identify mutable factors that impact access, continuity, utilization, quality, value, and outcomes, including disparities in outcomes, or scalability of mental health services; 2) Develop and test new research tools, technologies, measures, or methods and statistical approaches to study these issues; and/or 3) Integrate and analyze large data sets (e.g., data from electronic health records, claims data, or other administrative data) to understand factors affecting mental health services use, quality, and outcomes using sophisticated computational and predictive analytic approaches.
All Signature Research Projects should be directly linked to the Centers primary problem focus and should follow the deployment-focused model of intervention and services design and testing that characterizes the overall ALACRITY center. It is expected that these projects will have highly innovative cross-disciplinary linkages and high-risk/high-pay-off components designed to address the identified unmet mental health needs of the target population. Describe the feasibility of the proposed research study, the advantages of any new methodologies, potential pitfalls, and alternative approaches for the project and how these might impact on progress in the overall Center.
Describe the anticipated interactions between this project and other components of the Center and anticipated progress in the overall Center.
Letters of Support: Include letters of support relevant to the project.
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification: Consolidate l information on the sharing of resources in the Administrative Core.
Section 2 - Study Population Characteristics
2.5 Recruitment and Retention Plan
Applications must include a single attachment that clearly describes the following information:
Participant Recruitment and Retention Procedures:
3.1 Protection of Human Subjects
When preparing your application, use Component Type ‘Exploratory Research Project.
Phs 398 cover page supplement (exploratory research projects), research & related other project information (exploratory research projects), project /performance site location(s) (exploratory research projects), research & related senior/key person profile (exploratory research projects), budget (exploratory research projects), phs 398 research plan (exploratory research projects).
Specific Aims: The specific aims should provide a concise description of the aims of the project.
Significance: Describe overall goals and the impact of the science proposed in the project in relation to the state-of-the-art of the field. Explain the contribution of the project to the overall goals of the Center, how the project will interact with and benefit from other components of the Center and the appropriateness of the center approach and environment.
Innovation : Describe the unique and innovative contributions that will be made by the research project. Explain how these contributions will synergize with the rest of the Center to achieve more than what could be achieved through an independent research project. Detail how research projects propose novel, transdisciplinary, convergent solutions to intractable mental health problems by integrating input from experts with complementary expertise brought together in the ALACRITY Center.
Approach: Exploratory Research projects proposed for ALACRITY Centers should be designed to yield preliminary data of sufficient quality to guide the design of future, more definitive investigations centered on optimizing the effectiveness of therapeutic or preventive interventions for mental disorders within well-defined target populations; organizing and delivering optimized mental health services within clinical or community practice settings; or continuously improving the quality, impact, and durability of optimized interventions and service delivery strategies within multiple care systems.
Detail how the Exploratory Research Project is designed to:
Exploratory Research Projects involving Clinical Trials :
Other exploratory research projects might include services research that is consistent with NIMH's Strategic Plan and the Centers focus, but is not immediately focused on development and testing of services interventions. Such research should be modeled on the NIMH exploratory R34 mechanism for Pilot Services Research Grants Not Involving Clinical Trials ( PAR-23-105 ) and might include studies focused on: 1) identifying and elucidating mutable factors that impact access, utilization, quality, financing, outcomes including disparities in outcomes, or scalability of mental health services, to identify potential targets for future intervention development; 2) developing and validating of new research tools, measures, or methods; or 3) testing the feasibility of integrating existing data sets to understand factors affecting access, quality, delivery or outcomes of care; and 4) piloting strategies for learning mental health care system models as a means to enable practical studies of the value and effectiveness of services and treatments.
The content of all Exploratory Research Projects should be directly linked to the Centers primary focus and should follow the deployment-focused model of intervention and services design and testing that characterizes the overall ALACRITY Center. It is expected that these projects will have highly innovative cross-disciplinary linkages and high-risk/high-pay-off components designed to address the identified unmet mental health needs of the target population. Describe the feasibility of the proposed research study, the advantages of any new methodologies, potential pitfalls, and alternative approaches for the project and how these might impact on progress in the overall Center.
Describe the anticipated interactions between this project and other components of the Center and anticipated progress in the overall Center.
Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification: Consolidate all information on the sharing of resources in the Administrative Core.
2.5 Recruitment and Retention Plan
3. Unique Entity Identifier and System for Award Management (SAM)
See Part 1. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov
4. Submission Dates and Times
Part I. Overview Information contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or Federal holiday , the application deadline is automatically extended to the next business day.
Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies) using ASSIST or other electronic submission systems. Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIHs electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the NIH Policy on Late Application Submission.
Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.
Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide.
5. Intergovernmental Review (E.O. 12372)
This initiative is not subject to intergovernmental review .
6. Funding Restrictions
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement .
Pre-award costs are allowable only as described in the NIH Grants Policy Statement .
Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.
For information on how applications will be automatically assembled for review and funding consideration after submission, refer to: http://grants.nih.gov/grants/ElectronicReceipt/files/Electronic_Multi-project_Application_Image_Assembly.pdf .
Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
For assistance with your electronic application or for more information on the electronic submission process, visit How to Apply – Application Guide . If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the Dealing with System Issues guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.
Important reminders:
All PD(s)/PI(s) and component Project Leads must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form . Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH.
The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organizations profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide .
Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH. Applications that are incomplete or non-compliant will not be reviewed.
Use of Common Data Elements in NIH-funded Research
Many NIH ICs encourage the use of common data elements (CDEs) in basic, clinical, and applied research, patient registries, and other human subject research to facilitate broader and more effective use of data and advance research across studies. CDEs are data elements that have been identified and defined for use in multiple data sets across different studies. Use of CDEs can facilitate data sharing and standardization to improve data quality and enable data integration from multiple studies and sources, including electronic health records. NIH ICs have identified CDEs for many clinical domains (e.g., neurological disease), types of studies (e.g. genome-wide association studies (GWAS)), types of outcomes (e.g., patient-reported outcomes), and patient registries (e.g., the Global Rare Diseases Patient Registry and Data Repository). NIH has established a Common Data Element (CDE) Resource Portal" ( http://cde.nih.gov/ ) to assist investigators in identifying NIH-supported CDEs when developing protocols, case report forms, and other instruments for data collection. The Portal provides guidance about and access to NIH-supported CDE initiatives and other tools and resources for the appropriate use of CDEs and data standards in NIH-funded research. Investigators are encouraged to consult the Portal and describe in their applications any use they will make of NIH-supported CDEs in their projects.
NIMH expects investigators for this funding announcement to collect Common Data Elements (CDEs) for mental health human subjects research. Unless NIMH stipulates otherwise during the negotiation of the terms and conditions of a grant award, this Notice applies to all grant applications involving human research participants. The necessary funds for collecting and submitting these CDE data from all research participants to the NIMH Data Archive (NDA) should be included in the requested budget. A cost estimator ( https://nda.nih.gov/ndarpublicweb/Documents/NDA_Data_Submission_Costs.xlsx ) is available to facilitate the calculation of these costs. NIMH may seek further information regarding CDEs prior to award. Additional information about CDEs can be found at the NIMH webpage on Data Sharing for Applicants and Awardees .
Applicants are required to follow the instructions for post-submission materials, as described in the policy .
1. Criteria
Only the review criteria described below will be considered in the review process. Applications submitted to the NIH in support of the NIH mission are evaluated for scientific and technical merit through the NIH peer review system.
A proposed Clinical Trial application may include study design, methods, and intervention that are not by themselves innovative but address important questions or unmet needs. Additionally, the results of the clinical trial may indicate that further clinical development of the intervention is unwarranted or lead to new avenues of scientific investigation.
Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Reviewers will consider each of the review criteria below in the determination of scientific merit and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Significance
Does the project address an important problem or a critical barrier to progress in the field? Is the prior research that serves as the key support for the proposed project rigorous? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Specific to this NOFO:
How compelling is the justification for the Centers focus and the overall significance of the program of research in terms of:
In addition, for applications involving clinical trials
Are the scientific rationale and need for a clinical trial to test the proposed hypothesis or intervention well supported by preliminary data, clinical and/or preclinical studies, or information in the literature or knowledge of biological mechanisms? For trials focusing on clinical or public health endpoints, is this clinical trial necessary for testing the safety, efficacy or effectiveness of an intervention that could lead to a change in clinical practice, community behaviors or health care policy? For trials focusing on mechanistic, behavioral, physiological, biochemical, or other biomedical endpoints, is this trial needed to advance scientific understanding?
Investigator(s)
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or those in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?
With regard to the proposed leadership for the project, do the PD/PI(s) and key personnel have the expertise, experience, and ability to organize, manage and implement the proposed clinical trial and meet milestones and timelines? Do they have appropriate expertise in study coordination, data management and statistics? For a multicenter trial, is the organizational structure appropriate and does the application identify a core of potential center investigators and staffing for a coordinating center?
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed?
Does the design/research plan include innovative elements, as appropriate, that enhance its sensitivity, potential for information or potential to advance scientific knowledge or clinical practice?
Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Have the investigators included plans to address weaknesses in the rigor of prior research that serves as the key support for the proposed project? Have the investigators presented strategies to ensure a robust and unbiased approach, as appropriate for the work proposed? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? Have the investigators presented adequate plans to address relevant biological variables, such as sex, for studies in vertebrate animals or human subjects?
If the project involves human subjects and/or NIH-defined clinical research, are the plans to address:
1) the protection of human subjects from research risks, and 2) inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of individuals of all ages (including children and older adults), justified in terms of the scientific goals and research strategy proposed?
Does the application adequately address the following, if applicable
Study Design
Is the study design justified and appropriate to address primary and secondary outcome variable(s)/endpoints that will be clear, informative and relevant to the hypothesis being tested? Is the scientific rationale/premise of the study based on previously well-designed preclinical and/or clinical research? Given the methods used to assign participants and deliver interventions, is the study design adequately powered to answer the research question(s), test the proposed hypothesis/hypotheses, and provide interpretable results? Is the trial appropriately designed to conduct the research efficiently? Are the study populations (size, gender, age, demographic group), proposed intervention arms/dose, and duration of the trial, appropriate and well justified?
Are potential ethical issues adequately addressed? Is the process for obtaining informed consent or assent appropriate? Is the eligible population available? Are the plans for recruitment outreach, enrollment, retention, handling dropouts, missed visits, and losses to follow-up appropriate to ensure robust data collection? Are the planned recruitment timelines feasible and is the plan to monitor accrual adequate? Has the need for randomization (or not), masking (if appropriate), controls, and inclusion/exclusion criteria been addressed? Are differences addressed, if applicable, in the intervention effect due to sex/gender and race/ethnicity?
Are the plans to standardize, assure quality of, and monitor adherence to, the trial protocol and data collection or distribution guidelines appropriate? Is there a plan to obtain required study agent(s)? Does the application propose to use existing available resources, as applicable?
Data Management and Statistical Analysis
Are planned analyses and statistical approach appropriate for the proposed study design and methods used to assign participants and deliver interventions? Are the procedures for data management and quality control of data adequate at clinical site(s) or at center laboratories, as applicable? Have the methods for standardization of procedures for data management to assess the effect of the intervention and quality control been addressed? Is there a plan to complete data analysis within the proposed period of the award?
Environment
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
If proposed, are the administrative, data coordinating, enrollment and laboratory/testing centers, appropriate for the trial proposed?
Does the application adequately address the capability and ability to conduct the trial at the proposed site(s) or centers? Are the plans to add or drop enrollment centers, as needed, appropriate?
If international site(s) is/are proposed, does the application adequately address the complexity of executing the clinical trial?
If multi-sites/centers, is there evidence of the ability of the individual site or center to: (1) enroll the proposed numbers; (2) adhere to the protocol; (3) collect and transmit data in an accurate and timely fashion; and, (4) operate within the proposed organizational structure?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.
To what extent are the proposed milestones feasible, well developed, and quantifiable with regard to the specific aims for each project and core, and for the goals of the Center as a whole?
To what extent is(are) the Administrative Core leader(s) qualified and experienced in the administration of a large, multi-component research program?
How strong are the plans to incorporate opportunities for students, postdoctoral researchers, and early-career investigators? How will the plans for developing new research opportunities and integrating them with ongoing training at the participating institution(s) benefit early career researchers? How likely is it that the specific strategies that are proposed will promote cross-fertilization of ideas and facilitate new investigators exposure to potential consultants and collaborators (e.g., in-house lecture series, webinars, visiting scholars series, meetings with potential practice partners from new community settings)?
How likely is it that the plans for soliciting, reviewing, and selecting pilot feasibility projects of 1-2 years duration will yield meritorious pilot projects consistent with the Center focus? How strong are the plans for outreach to relevant investigator audiences, including early-career investigators, to advertise Center opportunities for support for pilot feasibility studies; how likely is it that the outreach plan will yield strong applications? How likely is it that the proposed plan for evaluating the merit of potential pilot feasibility studies will yield pilot projects that will position the Center investigators for subsequent research that advances and extends the Centers overall program of research?
How likely is it that the plans for establishing partnerships with key mental health stakeholders – e.g., service users, family members, clinicians, payers – will help Center investigators identify unmet mental health needs within the target population, develop and refine strategies for optimizing interventions and services, inform research topics, and maximize the external validity of ALACRITY research findings?
How strong are the plans for coordinating the evaluation of the Centers research activities and public health impact, with input from the Methods Core? To what extent will the evaluation plan be useful for iteratively refining the Centers ongoing activities and informing plans for future collaborative research?
To what extent will the dissemination plan facilitate reach a broad audience and increase science literacy? How likely is it that the plans for developing and maintaining a website and overall plans for disseminating/sharing research-generated resources (e.g., data, analytic strategies, assessment and intervention tools) will advance research and clinical purposes? To what extent will the proposed plans promote dissemination of research results to both scientific audiences and relevant stakeholders (service users, providers, policy makers)?
To what extent will the qualifications, past performance (if applicable), and time commitments of the Methods Core Leader(s) contribute to the likely success of the Center? Evaluate the appropriateness of the expertise for carrying out the functions proposed for the core.
Research Projects
How well does the project complement and contribute to the Center as a whole? How well is the project integrated with the scientific objectives of the Center?
How qualified is the Research Project Leader? Is the Research Project leader at the forefront of the area of science proposed?
To what extent is the project original and innovative?
For projects that involve clinical trials :
For Signature Projects :
For Exploratory Research Projects :
Study Timeline
Specific to applications involving clinical trials
Is the study timeline described in detail, taking into account start-up activities, the anticipated rate of enrollment, and planned follow-up assessment? Is the projected timeline feasible and well justified? Does the project incorporate efficiencies and utilize existing resources (e.g., CTSAs, practice-based research networks, electronic medical records, administrative database, or patient registries) to increase the efficiency of participant enrollment and data collection, as appropriate?
Are potential challenges and corresponding solutions discussed (e.g., strategies that can be implemented in the event of enrollment shortfalls)?
Protections for Human Subjects
For research that involves human subjects but does not involve one of the categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or more of the categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials. For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Subjects .
Inclusion of Women, Minorities, and Individuals Across the Lifespan
When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of individuals of all ages (including children and older adults) to determine if it is justified in terms of the scientific goals and research strategy proposed. For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion in Clinical Research .
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following criteria: (1) description of proposed procedures involving animals, including species, strains, ages, sex, and total number to be used; (2) justifications for the use of animals versus alternative models and for the appropriateness of the species proposed; (3) interventions to minimize discomfort, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with the AVMA Guidelines for the Euthanasia of Animals. Reviewers will assess the use of chimpanzees as they would any other application proposing the use of vertebrate animals. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animals Section .
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Resubmissions
For Resubmissions, the committee will evaluate the application as now presented, taking into consideration the responses to comments from the previous scientific review group and changes made to the project.
For Renewals, the committee will consider the progress made in the last funding period, including progress at: completing and disseminating results of the Center's Signature and Exploratory research projects; supporting and completing additional R03-like projects, including projects that include early-career investigators as project leads or collaborators; applying for and securing extramural support for additional research, including applications to NIH and other sources and applications that include early career investigators and trainees; generating and sharing resources, including tools for assessment, intervention, and analysis; and success at cultivating new research directions and collaborations, including partnerships with stakeholders and collaborations with investigators who contributes transdisciplinary expertise.
For Revisions, the committee will consider the appropriateness of the proposed expansion of the scope of the project. If the Revision application relates to a specific line of investigation presented in the original application that was not recommended for approval by the committee, then the committee will consider whether the responses to comments from the previous scientific review group are adequate and whether substantial changes are clearly evident.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.
Applications from Foreign Organizations
Select Agent Research
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Resource Sharing Plans
Reviewers will comment on whether the Resource Sharing Plan(s) (e.g., Sharing Model Organisms ) or the rationale for not sharing the resources, is reasonable.
Authentication of Key Biological and/or Chemical Resources:
For projects involving key biological and/or chemical resources, reviewers will comment on the brief plans proposed for identifying and ensuring the validity of those resources.
Budget and Period of Support
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
2. Review and Selection Process
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by NIMH, in accordance with NIH peer review policy and procedures , using the stated review criteria. Assignment to a Scientific Review Group will be shown in the eRA Commons.
As part of the scientific peer review, all applications will receive a written critique.
Applications may undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact score.
Appeals of initial peer review will not be accepted for applications submitted in response to this NOFO.
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended. Following initial peer review, recommended applications will receive a second level of review by the National Advisory Mental Health Council. The following will be considered in making funding decisions:
3. Anticipated Announcement and Award Dates
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons . Refer to Part 1 for dates for peer review, advisory council review, and earliest start date.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement .
1. Award Notices
If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant as described in the NIH Grants Policy Statement .
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization for successful applications. The NoA signed by the grants management officer is the authorizing document and will be sent via email to the recipient's business official.
Recipients must comply with any funding restrictions described in Section IV.6. Funding Restrictions. Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this NOFO will be subject to terms and conditions found on the Award Conditions and Information for NIH Grants website. This includes any recent legislation and policy applicable to awards that is highlighted on this website.
The NIMH has published policies and guidance for investigators regarding human research protection, data and safety monitoring, Independent Safety Monitors and Data and Safety Monitoring Boards, reportable events, and participant recruitment monitoring ( NOT-MH-19-027 ). The applications PHS Human Subjects and Clinical Trials Information should reflect the manner in which these policies will be implemented for each study record. These plans will be reviewed by the NIMH for consistency with NIMH and NIH policies and federal regulations. The NIMH will expect clinical trials to be conducted in accordance with these policies including, but not limited to: timely registration to ClinicalTrials.gov, submission of review determinations from the clinical trials data and safety monitoring entity (at least annually), timely submission of reportable events as prescribed, and establishment of recruitment milestones and progress reporting.
Individual awards are based on the application submitted to, and as approved by, the NIH and are subject to the IC-specific terms and conditions identified in the NoA.
ClinicalTrials.gov: If an award provides for one or more clinical trials. By law (Title VIII, Section 801 of Public Law 110-85), the "responsible party" must register and submit results information for certain applicable clinical trials on the ClinicalTrials.gov Protocol Registration and Results System Information Website ( https://register.clinicaltrials.gov ). NIH expects registration and results reporting of all trials whether required under the law or not. For more information, see https://grants.nih.gov/policy/clinical-trials/reporting/index.htm
Institutional Review Board or Independent Ethics Committee Approval: Grantee institutions must ensure that all protocols are reviewed by their IRB or IEC. To help ensure the safety of participants enrolled in NIH-funded studies, the recipient must provide NIH copies of documents related to all major changes in the status of ongoing protocols.
Data and Safety Monitoring Requirements: The NIH policy for data and safety monitoring requires oversight and monitoring of all NIH-conducted or -supported human biomedical and behavioral intervention studies (clinical trials) to ensure the safety of participants and the validity and integrity of the data. Further information concerning these requirements is found at http://grants.nih.gov/grants/policy/hs/data_safety.htm and in the application instructions (SF424 (R&R) and PHS 398).
Investigational New Drug or Investigational Device Exemption Requirements: Consistent with federal regulations, clinical research projects involving the use of investigational therapeutics, vaccines, or other medical interventions (including licensed products and devices for a purpose other than that for which they were licensed) in humans under a research protocol must be performed under a Food and Drug Administration (FDA) investigational new drug (IND) or investigational device exemption (IDE).
Prior Approval of Pilot Projects
Recipient-selected projects that involve {clinical trials or studies involving greater than minimal risk to human subjects} require prior approval by NIH prior to initiation.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities , including of note, but not limited to:
If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.
Should the applicant organization successfully compete for an award, recipients of federal financial assistance (FFA) from HHS will be required to complete an HHS Assurance of Compliance form (HHS 690) in which the recipient agrees, as a condition of receiving the grant, to administer programs in compliance with federal civil rights laws that prohibit discrimination on the basis of race, color, national origin, age, sex and disability, and agreeing to comply with federal conscience laws, where applicable. This includes ensuring that entities take meaningful steps to provide meaningful access to persons with limited English proficiency; and ensuring effective communication with persons with disabilities. Where applicable, Title XI and Section 1557 prohibit discrimination on the basis of sexual orientation, and gender identity, The HHS Office for Civil Rights provides guidance on complying with civil rights laws enforced by HHS. See https://www.hhs.gov/civil-rights/for-providers/provider-obligations/index.html and https://www.hhs.gov/civil-rights/for-individuals/nondiscrimination/index.html .
HHS recognizes that research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigators scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.
Please contact the HHS Office for Civil Rights for more information about obligations and prohibitions under federal civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697.
In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Defense Authorization Act of Fiscal Year 2009 (Public Law 110-417), NIH awards will be subject to the Federal Awardee Performance and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any information about itself that a federal agency previously entered and is currently in FAPIIS. The Federal awarding agency will consider any comments by the applicant, in addition to other information in FAPIIS, in making a judgement about the applicants integrity, business ethics, and record of performance under Federal awards when completing the review of risk posed by applicants as described in 45 CFR Part 75.205 and 2 CFR Part 200.206 Federal awarding agency review of risk posed by applicants. This provision will apply to all NIH grants and cooperative agreements except fellowships.
3. Data Management and Sharing
Note: The NIH Policy for Data Management and Sharing is effective for due dates on or after January 25, 2023.
Consistent with the NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the NIH Grants Policy Statement . Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described. If additional Data Management and Sharing requirements need to be added, please insert what requirements are desired.
When multiple years are involved, recipients will be required to submit the Research Performance Progress Report (RPPR) annually and financial statements as required in the NIH Grants Policy Statement.
Progress reports should briefly describe status of pilot projects, including data and safety monitoring, and should notify NIH of serious adverse events and unanticipated problems.
A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement . NIH NOFOs outline intended research goals and objectives. Post award, NIH will review and measure performance based on the details and outcomes that are shared within the RPPR, as described at 45 CFR Part 75.301 and 2 CFR Part 200.301.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for recipients of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All recipients of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over the threshold. See the NIH Grants Policy Statement for additional information on this reporting requirement.
In accordance with the regulatory requirements provided at 45 CFR 75.113and 2 CFR Part 200.113 and Appendix XII to 45 CFR Part 75 and 2 CFR Part 200, recipients that have currently active Federal grants, cooperative agreements, and procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 for any period of time during the period of performance of a Federal award, must report and maintain the currency of information reported in the System for Award Management (SAM) about civil, criminal, and administrative proceedings in connection with the award or performance of a Federal award that reached final disposition within the most recent five-year period. The recipient must also make semiannual disclosures regarding such proceedings. Proceedings information will be made publicly available in the designated integrity and performance system (currently FAPIIS). This is a statutory requirement under section 872 of Public Law 110-417, as amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75and 2 CFR Part 200 – Award Term and Condition for Recipient Integrity and Performance Matters.
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threaten submission by the due date, and post-submission issues)
Finding Help Online: https://www.era.nih.gov/need-help (preferred method of contact) Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources) Email: [email protected] (preferred method of contact) Telephone: 301-480-7075
Grants.gov Customer Support (Questions regarding Grants.gov registration and Workspace) Contact Center Telephone: 800-518-4726 Email: [email protected]
Joel Sherrill, Ph.D. National Institute of Mental Health (NIMH) Telephone: 301-443-2477 Email: [email protected]
Nicholas Gaiano, Ph.D. National Institute of Mental Health (NIMH) Telephone: 301-827-3420 Email: [email protected]
Tamara Kees National Institute of Mental Health (NIMH) Telephone: 301-443-8811 Email: [email protected]
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts . All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement .
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Part 75 and 2 CFR Part 200.
Color Scheme
Elon Musk’s X, the social media site formerly known as Twitter, has become more popular with conservative users and those who identify with the political right since Musk’s takeover in late 2022, according to a new Pew Research Center report.
The percentage of Republican users who think X is “mostly good” for American democracy has more than tripled since Musk purchased the site in October 2022. The year before Musk’s takeover, in 2021, only 17% of users who identified as Republicans believed the site was good for democracy. Now, after Musk has platformed and amplified right-leaning leaders and viewpoints, that figure has jumped to 53%, according to a Pew Research Center survey of more than 10,200 US adults conducted in March of this year and released on Wednesday.
Across the aisle, feelings have moved in the other direction. In 2021, 47% of Democrats surveyed said they thought Twitter was mostly good for democracy. Now, more than 18 months after Musk’s takeover, just 26% of Democratic users think X is good for democracy.
Musk has turned X into a site where Republican viewpoints are more widely accepted, and where right-leaning users report significantly less harassment than their liberal counterparts. More than half of Republicans who post about politics on X believe their views “feel welcome,” compared to just a third of Democrats, according to the report. Left-leaning users are also more than three times as likely to say harassment is a “major problem” on X.
When Musk purchased Twitter in 2022, he was openly critical of the network’s left-leaning employee base and reputation. He posted publicly about his desire to support free speech and create an open town square where all voices could be heard, not just the “far far left San Francisco views” that he claimed dominated the site.
Since then, the mercurial billionaire has courted and platformed conservative and right-wing politicians around the world, including reversing a ban on former President Donald Trump, and has spread conspiracy theories and amplified extremist views. He has coupled those efforts with regular attacks on President Joe Biden, whom he has called “a grim puppet” for the Democratic party.
It’s a combination that has made X a much more attractive and welcome place for political conservatives, especially in the US. The Pew Research Center report comes just five months ahead of the 2024 US Presidential election, where social media sites, including X, have historically played a prominent role. Political conversations on X have been a key part of the service for over a decade, and X has played a central role in the Arab Spring uprising, Donald Trump’s 2020 presidential campaign and the Israel-Hamas war, among other events. Nearly 75% of users on X said they come across political content as they browse the site, according to Pew.
While social media is regularly used by politicians to reach voters, other social network CEOs like Meta Platforms Inc.’s Mark Zuckerberg have attempted to hide their political viewpoints, refusing to publicly promote or endorse a specific candidate. While Musk has not yet endorsed Trump, he’s been very public about his political leanings and his intention to push X toward the right.
The X owner, who has more than 187 million followers, has shared and commented on posts that espouse views considered conservative, including some that criticize immigration, spread anti-trans narratives and discredit diversity, equity and inclusion policies.
Republican politicians are leaning into this change at X. In May of last year, for example, Musk hosted Florida Governor Ron DeSantis as he announced his 2024 presidential campaign on X – the first event of its kind on social media. This year, X will also host a town hall event with Trump ahead of the election. Biden, who was also invited to participate in a town hall on X, declined.
The cost of borrowing has risen sharply in recent years, so when it comes to tackling a big expense, it’s important to know about the options.
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The X-12 research center is a location in Big MT in 2281. It is located directly southwest of the Think Tank. An upgraded sonic emitter pistol is needed to get past the force field blocking the stairs going down. On the bottom floor below, the Y-17 master trauma harness is wandering around. After disposing of it, three more Y-17 trauma override harness entities will spawn at the front door ...
The X-12 research center is a location in Big MT in 2281. X-12 is directly southwest of The Think Tank. An upgraded sonic emitter is required to get past the force field blocking the stairs going down. On the bottom floor below, the Y-17 master trauma harness is wandering around. After disposing of it, three more Y-17 trauma override harnesses will spawn at the front door. There are three ...
Quests. Influencing People. "X-12 IS CLOSED UNTIL FURTHER NOTICE. ON AN UNRELATED NOTE, WHOEVER CLOSED X-12, PLEASE REPORT TO THE DOME.". — Doctor Klein. The X-12 Research Center is a location in Big MT in Fallout: New Vegas. It is located directly southwest of the Think Tank .
X-12 Research CenterAn upgraded sonic emitter pistol is needed to get past the force field blocking the stairs going down. On the bottom floor below, the Y-1...
Part 41: Clearing the X-12 Lab then Heading to the Saturnite Alloy Research Facility (Fallout NV Gameplay)Click Here for Next Video: http://www.youtube.com/w...
X-12 RESEARCH CENTER ===== You enter into a small room. Further progress is blocked by a force field. Take down the field and an enemy, the Y-17 MASTER TRAUMA HARNESS attacks. When you kill it, 3 more TRAUMA OVERRIDE HARNESS enter the building and attack also. Kill them all then loot the building The MASTER HARNESS carries a [K9000 CYBERDOG GUN ...
Please remember to leave a rating, helps me out a lot!You need a quest completed to complete it... Which either I wasn't told about skipped/didn't pay attent...
Location 2: The X-12 Research Center. The 2nd weapon is located behind a force field in the X-12 Research Center. To get past the force field, you'll have to get an upgrade for the Sonic Emitter, which enables it to turn off Big Mountain force fields. To do this, simply follow the Main Quest "Sonic Emitter Upgrade". This quest will be ...
Community content is available under CC-BY-SA unless otherwise noted. The X-12 research center terminal entries are a series of terminal entries in the Fallout: New Vegas add-on Old World Blues. They can be found on a terminal in the X-12 research center. These three entries can also be found on the X-8 Observatory terminal in the X-8 research ...
The X-12 Research Center terminals are a series of terminal entries at the X-12 research center in the Fallout: New Vegas add-on Old World Blues. Note: This desk terminal is located on the table on Level 1 of the facility. Copies of this correspondence is also legible at the X-8 research center...
I am trying to get in the X-12 Research Center. I am on the top level but there is a force field blocking my entry. I have no idea how to get in. I checked the wiki about some kind of emiter, but I don't understand, since it doesn't explain it. I tried shooting it with my Sonic Emitter- Revelation, but nothing is happening. So what am I suppose ...
This is the official community for Genshin Impact (原神), the latest open-world action RPG from HoYoverse. The game features a massive, gorgeous map, an elaborate elemental combat system, engaging storyline & characters, co-op game mode, soothing soundtrack, and much more for you to explore!
I'm particularly interested in getting through the force-fields in the x-12 building. baycitybrawler - 12 years ago - report. Top Voted Answer. As the game progresses you will be sent on a quest to get the item. In fact getting the proper emitter is part of the main story line. Be prepared, the opposition is tough.
Research facility. For a fact its all the way to the far East on the world map/ But you can just find it with your quest marker bro! OWB X-12 , Stuck. Quick reply please. For Fallout: New Vegas on the Xbox 360, a GameFAQs message board topic titled "OWB X-12 , Stuck. Quick reply please.".
For the x-12 research center . I need a gun that shoots energy shields and gets rid of them. The problem is I've already done all the dlcs, and the gun isn't in my inventory. I have no idea where it might be. Any help. Locked post. New comments cannot be posted. Share
In a pattern consistent with past Center studies on social media use, there are some stark age differences. Some 84% of adults ages 18 to 29 say they ever use any social media sites, which is similar to the share of those ages 30 to 49 who say this (81%). By comparison, a somewhat smaller share of those ages 50 to 64 (73%) say they use social ...
To better understand Americans' social media use, Pew Research Center surveyed 5,733 U.S. adults from May 19 to Sept. 5, 2023. Ipsos conducted this National Public Opinion Reference Survey (NPORS) for the Center using address-based sampling and a multimode protocol that included both web and mail. This way nearly all U.S. adults have a chance ...
In order to keep the Millennial generation analytically meaningful, and to begin looking at what might be unique about the next cohort, Pew Research Center decided a year ago to use 1996 as the last birth year for Millennials for our future work. Anyone born between 1981 and 1996 (ages 23 to 38 in 2019) is considered a Millennial, and anyone ...
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Style Guide Overview MLA Guide APA Guide Chicago Guide OWL Exercises. Purdue OWL. Research and Citation. APA Style (7th Edition) APA Style (7th Edition)
Elektrostal Geography. Geographic Information regarding City of Elektrostal. Elektrostal Geographical coordinates. Latitude: 55.8, Longitude: 38.45. 55° 48′ 0″ North, 38° 27′ 0″ East. Elektrostal Area. 4,951 hectares. 49.51 km² (19.12 sq mi) Elektrostal Altitude.
x-12 reseach center #1 (message deleted) d100Productions 12 years ago #2. ... You should of got it from the X-8 Research Center. Boards; Fallout: New Vegas - Old World Blues (X360) x-12 reseach center; Topic Archived; Product Deals. See All. Fanatical. $8.70 new More Topics from this Board. OWB A Brain's Best Friend quest bug Help.
Elektrostal is a city in Moscow Oblast, Russia, located 58 kilometers east of Moscow. Elektrostal has about 158,000 residents. Mapcarta, the open map.
40 Facts About Elektrostal. Elektrostal is a vibrant city located in the Moscow Oblast region of Russia. With a rich history, stunning architecture, and a thriving community, Elektrostal is a city that has much to offer. Whether you are a history buff, nature enthusiast, or simply curious about different cultures, Elektrostal is sure to ...
These are some of the key findings from a new Pew Research Center survey of about 10,000 U.S. adults conducted in March 2024. This is one of two Pew Research Center reports on habits and attitudes on different social media platforms from the Pew-Knight Initiative, a research program funded jointly by The Pew Charitable Trusts and the John S. and James L. Knight Foundation.
Purpose. This Notice of Funding Opportunity (NOFO) invites applications for center grants to support Advanced Laboratories for Accelerating the Reach and Impact of Treatments for Youth and Adults with Mental Illness (ALACRITY) Centers.The purpose of these research Centers is to support transdisciplinary teams of clinical and mental health services researchers, behavioral scientists, social ...
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In 1938, it was granted town status. [citation needed]Administrative and municipal status. Within the framework of administrative divisions, it is incorporated as Elektrostal City Under Oblast Jurisdiction—an administrative unit with the status equal to that of the districts. As a municipal division, Elektrostal City Under Oblast Jurisdiction is incorporated as Elektrostal Urban Okrug.
The Pew Research Center report comes just five months ahead of the 2024 US Presidential election, where social media sites, including X, have historically played a prominent role. Political ...
The University of British Columbia. Activities between the University of British Columbia and Exeter include a joint research symposium focused on Community, Culture, Creativity, and Wellbeing held at Exeter in May 2018 and a faculty-led, co-funded initiatives in Sport, Exercise and Health Sciences, Climate Change and Digital Humanities.