journal of experimental medicine brief definitive report

Medical Student Research Journal

Michigan state university college of human medicine.

Guidelines – Brief Report

Brief reports are similar to original research in that they follow the same rigor, format and guidelines, but are designed for small-scale research or research that is in early stages of development. These may include preliminary studies that utilize a simple research design or a small sample size and that have produced limited pilot data and initial findings that indicate need for further investigation. Brief reports are much shorter than manuscripts associated with a more advanced, larger-scale research project. They are not meant to be used for a short version of an article about research that would otherwise qualify for a full original research manuscript or for publishing material on research that lacks significance, is not rigorous or, if expanded, would not qualify for a full article or for research.

Order of Sections

Introduction

Illustrations (Figure/Tables)

Manuscript Limits

Total Length: up to 1500 words (not including abstract, illustrations, and references)
Abstract Length: up to 150 words
Table/Figure Limits: up to 3 tables and figures
References: up to 40 references

The title page should carry the following information:

Article Title (concise information about the study, limited to 100 characters)
Author Names (Mark D. Smith B.S. 1* , Jeremy Michael Howes M.S. 2 , Jessica P. Masters M.D. Ph. D. 1,2 )
Institutional Affiliations of all authors in order of appearance in author names ( 1 College of Human Medicine, Michigan State University, East Lansing, MI, USA. 2 Dept. of Internal Medicine, Michigan State University, East Lansing, MI, USA)
Contact information for corresponding author(s) including address, email, phone, and fax. The corresponding author should indicate clearly whether his or her e-mail address can be published. Corresponding author(s) is indicated with asterisk by name in author listing; the medical students should be corresponding author.
Short Title (50 character limit shorter title for headers)
Key Phrases – Relevant words or short phrases that aid search engines or indexes in finding your work (use MeSH headings if possible). Use key phrases that are not present in the title. Maximum of 6, e.g. (Pemphigus, Bullous Skin Disorder, Autoimmune, Blistering, Skin Diseases, Monoclonal Antibody)
Disclaimers, if any
Word Count: Abstract and Body (excluding abstract, illustrations, and references)
Table and Figure Count
Source(s) of support in the form of grants, equipment, drugs, or all of these
Conflict of Interest Statement

Abstracts are the only substantive portion of the article indexed in many electronic databases, and the only portion many readers read. Authors must be careful that they accurately reflect the content of the article in the abstract. This description should include:

Context or background for the study
Purpose, basic procedures, main findings, and principal conclusions
Emphasis on new and important aspects of the study or observations
No references, illustrations, or references to illustrations are allowed in the abstract
The abstract should be structured with similar headings as in the main article (e.g. introduction, patient profile, interventions, conclusions)

Provide a context or background for the study including the nature of the problem and its significance to medical learners and scientists. State the specific purpose or research objective tested by the study; the research objective is often more sharply focused when stated as a question. Both the main and secondary objectives should be clear, and any pre-specified subgroup analyses should be described. Provide only directly pertinent references, and do not include data or conclusions from the work being reported.

The methods section should include information on materials, methods and procedures in sufficient detail such that the study can be repeated and/or validated. The methods section should include only information that was available at the time the plan or protocol for the study was being written; all information obtained during the study belongs in the results section. The methods section is comprised of the following subheadings (if applicable):

Selection and Description of Participants

Describe your selection of the observational or experimental participants clearly, including eligibility and exclusion criteria and a description of the source population. Explain the use of variables such as gender and age when they are included in a study report–for example, authors should explain why only participants of certain ages were included or why women were excluded. The guiding principle should be clarity about how and why a study was done in a particular way.

Technical Information

Identify the methods, apparatus (give the manufacturer’s name, city, and state in parentheses), and procedures in sufficient detail to allow others to reproduce the results. Give references to established methods, including statistical methods, describe new or substantially modified methods, give the reasons for using them, and evaluate their limitations.

Describe statistical methods with enough detail to enable a knowledgeable reader with access to the original data to verify the reported results. Avoid relying solely on statistical hypothesis testing, such as p-values, which fail to convey important information about effect size, but include averages with confidence intervals if available, in addition to the p-values. Define statistical terms, abbreviations, and most symbols. Specify the computer software used.

Present your results in logical sequence in the text, tables, and illustrations, giving the main or most important findings first. Do not repeat all the data in the tables or illustrations in the text; emphasize or summarize only the most important observations. Extra or supplementary materials and technical detail can be placed in an appendix. Restrict tables and figures to those needed to explain the argument of the paper and to assess supporting data. Avoid interpreting the data, as this section is pure information that the reader can interpret for themselves; the authors’ own interpretation of the data is meant for the discussion section of the manuscript.

Emphasize the new and important aspects of the study and the conclusions that follow from them. For experimental studies, it is useful to begin the discussion by summarizing briefly the main findings, then explore possible mechanisms or explanations for these findings, compare and contrast the results with other relevant studies, state the limitations of the study, and explore the implications of the findings for future research and for clinical practice.

Limitations : Because every experiment or project can always be improved, a healthy discussion of the limitations of the study should be included. All manuscripts should include a brief discussion on the adequacy of the research methods to draw a valid conclusion. Authors should comment on changes that would improve the methods of the study or reasons why the methods are able to draw a strong conclusion. The discussion of limitations should not be a separate heading or sub-heading in the actual manuscript, but should be a flowing part of the discussion section.

Please see the directions for formatting References .

Illustrations (Figures and Tables)

Should follow the same format as mentioned in the General Guidelines .

The Medical Student Research Journal is a scholarly journal by medical students supported by Michigan State University College of Human Medicine.

Authors grant unrestricted copyright license to MSRJ while retaining full copyright to their works. This means authors may distribute their work at their discretion, but may not alter the final product as published by MSRJ. Permissions for reproduction of final published article are granted by MSRJ, while pre-publication works are distributable at authors’ discretion.

Michigan State University logos used with permission.

Privacy Statement

The names and email addresses entered in this journal site will be used exclusively for the stated purposes of this journal and will not be made available for any other purpose or to any other party.

Disclosures Please view our disclosures available on the general guidelines here .

This page was last updated on 2/15/2014 KCP.

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Vol. 221
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The Geriatric Nutritional Risk Index (GNRI) is a popular nutritional screening tool. However, the calculation of ideal body weight (IBW) differs among studies. We aimed to compare GNRI calculated using the Lorentz formula (LF) with a body mass index (BMI) and to investigate the cutoffs based on original or quartile criteria for the association with mortality in elderly patients in Japan. This retrospective study enrolled patients aged 65 and older in a long-term care hospital. The GNRI was calculated using two different IBW methods: the LF and a BMI of 22 kg/m 2 . We categorized GNRI results based on the original criteria or quartile criteria. Mortality outcomes were analyzed using the GNRI based on IBW (LF or BMI) and its classification (original criteria or quartile) through Cox proportional hazard regression. There were 262 participants, including 160 women, with a median age of 86. There was a notable difference between GNRI-BMI and GNRI-LF. The GNRI-LF original and quartile criteria did not show an association with mortality. A significant association with mortality was found between Q1 and Q4 in the GNRI-BMI quartile criteria (hazard ratio: 2.60; 95% confidence interval: 1.66-4.07, p < 0.01), but not the GNRI-BMI original criteria. The GNRI calculated using BMI with quartile criteria proved to be a reliable predictor of mortality for Japanese elderly inpatients. The calculation method of GNRI and the appropriate cutoff point should be considered based on the patient’s background.

Specific, measurable, achievable, relevant, timed (SMART) principle improves the nursing utility by setting individual goals for participants and helping them to achieve these goals. Our study intended to investigate the impact of a SMART nursing project on reducing mental stress and post-traumatic stress disorder (PTSD) in parents of childhood or adolescent osteosarcoma patients. In this randomized, controlled study, 66 childhood or adolescent osteosarcoma patients and 126 corresponding parents were enrolled and divided into SMART or normal care (NC) groups at a 1:1 ratio. All parents received a 3-month corresponding intervention and a 6-month interview. Our study revealed that the self-rating anxiety scale score at the 3rd month (M3) ( P < 0.05) and the 6th month (M6) ( P < 0.01), and anxiety rate at M3 ( P < 0.05) and M6 ( P < 0.05) were lower in parents in SMART group vs. NC group. The self-rating depression scale score at M3 and M6, and depression rate at M3 and M6 were lower in parents in SMART group vs. NC group (all P < 0.05). Impact of events scale-revised score at the 1st month (M1) ( P < 0.05), M3 ( P < 0.05), and M6 ( P < 0.01) were lower in parents in SMART group vs. NC group. By subgroup analyses, the SMART nursing project showed better impacts on decreasing anxiety, depression, and PTSD in parents with an undergraduate education or above than in those with a high school education or less. Conclusively, SMART nursing project reduces anxiety, depression, and PTSD in parents of childhood or adolescent osteosarcoma patients, which is more effective in those with higher education.

Selective dorsal rhizotomy (SDR) has been used to treat children with spastic cerebral palsy (CP), and its beneficial effect on quality of life and ambulation has been confirmed in long-term follow-up studies. However, the role of SDR in the treatment of spasticity in patients with hereditary spastic paraplegia (HSP) and related disorders is not well-established. Here, we report the first patient with the ZC4H2 variant who underwent SDR to treat spastic paraplegia. Abnormal gait was discovered during a regular checkup at the age of 3 years and 9 months, and she was diagnosed with spastic paraplegia. She was heterozygous for the ZC4H2 variant and underwent SDR at the age of 5 years and 11 months, which alleviated the spasticity. The patient underwent inpatient postoperative rehabilitation for 4 months and continued outpatient physiotherapy after discharge. The Gross Motor Function Measure-88 score and maximum walking speed decreased transiently 1 month postoperatively, but gradually recovered, and continuously improved 6 months postoperatively. SDR and postoperative intensive rehabilitation were effective in improving motor and walking functions up to 6 months after surgery, although long-term follow-up is needed to draw conclusions.

Transcutaneous electrical nerve stimulation (TENS) has been used to reduce pain or improve motor function in musculoskeletal and neurological disorders in the clinic. Although some studies have suggested electrotherapy as an intervention for edema, the effects and mechanisms of TENS on inflammation-induced edema remain unclear. Thus, we aimed to investigate the effects of TENS on arthritic pain with edema. 1% carrageenan was injected into the right tibiofemoral joint of 69 male Sprague–Dawley rats (200-250 g). After the development of arthritic pain, low-frequency (4-Hz, Low-TENS, n = 25) and high-frequency (100-Hz, High-TENS, n = 25) TENS with sub-motor threshold or placebo-TENS (n = 19) was applied for 20-min to medio-lateral part of the ipsilateral side. Weight bearing and knee-bend tests were used to assess pain-like behaviors. Also, we examined the size of edema and measured tumor necrosis factor-alpha (TNF- α ) and interleukin-1 beta (IL-1 β ) levels in the synovium by western blot. Eight rats in each of the two TENS groups were injected with Naloxone. Edema was reduced in the low- and high-frequency TENS groups at 6-h. TENS-treated rats showed reduced pain in the knee-bend test at 6-h. We observed decreased weight load shifts on the ipsilateral side in TENS groups. Naloxone reduced these effects. TNF- α and IL-1 β expression decreased in the synovial membrane at 6-h. These results suggest that low- and high-frequency TENS have acutely positive effects on inflammatory edema, with the management of arthritic pain and reduction in pro-inflammatory mediators. Therefore, Low-TENS and High-TENS may be useful in treating acute inflammatory pain and edema.

Polo-like kinase 4 (PLK4) involves in tumor progression via regulating centriole duplication. This study aimed to investigate correlations of PLK4 with tumor characteristics and survival in cutaneous melanoma patients undergoing surgical resection. Tumor specimens of 43 patients were retrieved for PLK4 determination by immunohistochemistry (IHC). The IHC score was a multiplication of staining intensity and percentage of staining-positive cells. This study found the median and mean tumor PLK4 IHC score was 0.0 (interquartile range: 0.0-6.0) and 3.5 ± 3.2 (mean ± SD), respectively. Elevated tumor PLK4 IHC score correlated with lymph node metastasis ( P = 0.028), higher tumor node metastasis (TNM) stage ( P = 0.004), and adjuvant therapy ( P =0.029). Tumor PLK4 IHC score > 0 did not relate to disease-free survival (DFS) or overall survival (OS) (both P > 0.050). Tumor PLK4 IHC score > 3 associated with decreased DFS ( P = 0.027), but not OS ( P = 0.098). Five-year DFS rate of patients with tumor PLK4 IHC score = 0 and > 0 was 75.0% and 53.9%, correspondingly; while the rate of patients with the score ≤ 3 and > 3 was 81.0% and 37.5%, respectively. Five-year OS rate of patients with the score = 0 and > 0 was 100.0% and 66.3%, accordingly; whereas the rate of patients with the score ≤ 3 and > 3 was 85.7% and 61.5%, correspondingly. According to forward-step multivariate analysis, neither the score > 0 nor > 3 independently related to worse DFS and OS (all P > 0.050). Further validation via THE HUMAN PROTEIN ATLAS database showed high PLK4 RNA expression associated with shortened OS in melanoma patients ( P = 0.001). PLK4 correlates with lymph node metastasis, increased TNM stage, and poor DFS in cutaneous melanoma patients undergoing surgical resection.

Anamorelin (ANAM) is a novel ghrelin receptor agonist for the treatment of cancer cachexia. In clinical trials of ANAM, glucose metabolism disorders as adverse effects were relatively frequent, however, when and how they occur remains unclear. Moreover, the safety in patients with pancreatic cancer and/or diabetes has not been clarified because most previous studies focused on patients with non-small cell lung cancer and had excluded patients with poorly controlled diabetes. Herein, a 66-year-old man with advanced pancreatic cancer and diabetes was administered ANAM, and acute hyperglycemia was developed and could be monitored by the self-monitoring of blood glucose (SMBG). Increasing the insulin dose failed to control hyperglycemia adequately, but the hyperglycemia ameliorated quickly after ANAM discontinuation. The continuous glucose monitoring (CGM) revealed that the sensor glucose levels had remained in the high range throughout the day during ANAM administration despite using 1.5 times more insulin. Our report is one of the few that describe the details of ANAM-induced hyperglycemia and provides important information for the safe and effective use of ANAM.

Osimertinib, a promising and approved third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is a standard strategy for EGFR-mutant non-small cell lung cancer (NSCLC) patients. However, developed resistance is unavoidable, which reduces its long-term effectiveness. In this study, RNA sequencing was performed to analyze differentially expressed genes (DEGs). The PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA) were used to identify the key genes for clinical prognosis and gene correlation respectively. Protein expression was determined by western blot analysis. Cell viability assay and Ki67 staining were used to evaluate the effect of osimertinib on tumor cells. Finally, we screened out two hub genes, myelocytomatosis oncogene ( Myc ) and axis inhibition protein 1 ( Axin1 ), upregulated in three osimertinib-resistant cell lines through RNA sequencing and bioinformatics analysis. Next, cell experiment confirmed that expression of C-MYC and AXIN1 were elevated in different EGFR mutant NSCLC cell lines with acquired resistance to osimertinib, compared with their corresponding parental cell lines. Furthermore, we demonstrated that AXIN1 upregulated the expression of C-MYC and mediated the acquired resistance of EGFR mutant NSCLC cells to osimertinib in vitro . In conclusion, AXIN1 affected the sensitivity of EGFR mutant NSCLC to osimertinib via regulating C-MYC expression in vitro . Targeting AXIN1/MYC signaling may be a potential new strategy for overcoming acquired resistance to osimertinib.

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Long covid is not a functional neurologic disorder.

1. Introduction

2. pathobiological disease characterization: from neurasthenia to myalgic encephalomyelitis/chronic fatigue syndrome, 3. psychosomatic/sociogenic illness construction: from neurasthenia to functional neurologic disorder.

One or more symptoms of altered voluntary motor behavior or sensory function
Clinical findings provide evidence of incompatibility between the symptom and recognized neurological or medical conditions
The symptom or deficit is not better explained by another medical or mental disorder
The symptom or deficit causes clinically significant distress or impairment in social, occupational, or other important areas of functioning, or warrants medical evaluation

4. Evidence Refutes That Long COVID Should Be Considered a Functional Neurologic Disorder

Autonomic conditions , such as neurocardiogenic syncope, postural orthostatic tachycardia syndrome, orthostatic intolerance, and autonomic and small fiber neuropathy
Chronic pain conditions , such as fibromyalgia, myofascial pain syndrome, and complex regional pain syndrome
Systemic immune conditions , such as mast cell activation syndrome and mastocytosis
Autoimmune conditions , such as Sjögren’s syndrome, systemic lupus erythematosus, and anti-phospholipid syndrome
Genetic conditions , such as hypermobile Ehlers-Danlos syndrome and other hypermobility spectrum disorders, Fabry’s disease and others
Mitochondrial and metabolic conditions
Infection-associated chronic conditions , such as myalgic encephalomyelitis, Long COVID/Post-COVID condition, and post-treatment Lyme disease

4.1. Refutative Evidence from Pathophysiology

4.2. refutative evidence from clinical presentation, 4.2.1. motor examination.

Findings	Long COVID	Functional Neurological Disorder







	)

4.2.2. Sensory Examination

4.2.3. tremor, 4.2.4. spells and seizures, 4.2.5. gait examination, 4.2.6. urinary functioning, 4.2.7. cognition, 4.2.8. summary, 4.3. refutative evidence from neuroimaging, 5. conclusions, author contributions, institutional review board statement, informed consent statement, data availability statement, conflicts of interest.

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Click here to enlarge figure

Clinical Feature	ME/CFS	Long COVID	FND
Post-exertional malaise/ Post-exertional neuroimmune exhaustion	Yes	Yes, some types	No
Pain	Yes	Yes, some types	Sometimes
Dizziness	Yes	Yes	No
Neuropathic features	Yes	Yes	No
Recurrent flu-like symptoms	Yes	Common	No
Dysautonomia	Yes	Common	No
Abnormal sleep study	Yes	Yes	No
Fatigue	Yes	Yes	Yes
Impaired sleep	Yes	Yes	Yes
Functional leg weakness	No	No	Yes
Functional seizures	No	No	Yes
Functional tremor	No	No	Yes
Functional dystonia	No	No	Yes
Functional gait disorder	No	No	Yes
Functional facial spasm	No	No	Yes
Functional tics	No	No	Yes
Functional drop attacks	No	No	Yes
Functional sensory symptoms	No	No	Yes
Functional cognitive symptoms	No	No	Yes
Functional speech and swallowing	No	No	Yes
Functional visual symptoms	No	No	Yes
Dissociative symptoms	No	No	Yes

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Share and Cite

Davenport, T.E.; Blitshteyn, S.; Clague-Baker, N.; Davies-Payne, D.; Treisman, G.J.; Tyson, S.F. Long COVID Is Not a Functional Neurologic Disorder. J. Pers. Med. 2024 , 14 , 799. https://doi.org/10.3390/jpm14080799

Davenport TE, Blitshteyn S, Clague-Baker N, Davies-Payne D, Treisman GJ, Tyson SF. Long COVID Is Not a Functional Neurologic Disorder. Journal of Personalized Medicine . 2024; 14(8):799. https://doi.org/10.3390/jpm14080799

Davenport, Todd E., Svetlana Blitshteyn, Nicola Clague-Baker, David Davies-Payne, Glenn J. Treisman, and Sarah F. Tyson. 2024. "Long COVID Is Not a Functional Neurologic Disorder" Journal of Personalized Medicine 14, no. 8: 799. https://doi.org/10.3390/jpm14080799

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Central Line-Associated Bloodstream Infection Misclassifications—Rethinking the Centers for Disease Control and Prevention’s Central Line-Associated Bloodstream Infection Definition and Its Implications

Critical Care Medicine. 52(3):357-361, March 2024.

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Feature Articles

Management of Heat-Related Illness and Injury in the ICU: A Concise Definitive Review

Critical Care Medicine. 52(3):362-375, March 2024.

Go to Full Text of this Article

The 2023 American Academy of Neurology, American Academy of Pediatrics, Child Neurology Society, and Society of Critical Care Medicine Pediatric and Adult Brain Death/Death by Neurologic Criteria Determination Consensus Guidelines: What the Critical Care Team Needs to Know*

Critical Care Medicine. 52(3):376-386, March 2024.

The Influence of Potential Organ Donors on Standardized Mortality Ratios and ICU Benchmarking*

Critical Care Medicine. 52(3):387-395, March 2024.

Ventilator Weaning and Terminal Extubation: Withdrawal of Life-Sustaining Therapy in Children. Secondary Analysis of the Death One Hour After Terminal Extubation Study

Critical Care Medicine. 52(3):396-406, March 2024.

Clinical Investigations

The Relationship Between Metabolic Syndrome and Mortality Among Patients With Acute Respiratory Distress Syndrome in Acute Respiratory Distress Syndrome Network and Prevention and Early Treatment of Acute Lung Injury Network Trials*

Critical Care Medicine. 52(3):407-419, March 2024.

Effect of a Standardized Family Participation Program in the ICU: A Multicenter Stepped-Wedge Cluster Randomized Controlled Trial*

Critical Care Medicine. 52(3):420-431, March 2024.

Improved 30-Day Survival Estimation in ICU Patients: A Comparative Analysis of Different Approaches With Real-World Data*

Critical Care Medicine. 52(3):432-440, March 2024.

Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial*

Critical Care Medicine. 52(3):441-451, March 2024.

Review Articles

In-Hospital Neurologic Complications, Neuromonitoring, and Long-Term Neurologic Outcomes in Patients With Sepsis: A Systematic Review and Meta-Analysis

Critical Care Medicine. 52(3):452-463, March 2024.

Left-Ventricular Unloading With Impella During Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis*

Critical Care Medicine. 52(3):464-474, March 2024.

Brief Report

A Transcriptomic Classifier Model Identifies High-Risk Endotypes in a Prospective Study of Sepsis in Uganda*

Critical Care Medicine. 52(3):475-482, March 2024.

Concise Definitive Review

Post-Cardiac Arrest Care in Adult Patients After Extracorporeal Cardiopulmonary Resuscitation

Critical Care Medicine. 52(3):483-494, March 2024.

Seeking Harmony—Determining Brain Death/Death by Neurologic Criteria Circa 2023*

Critical Care Medicine. 52(3):495-497, March 2024.

The Standardized Mortality Ratio and ICU Benchmarking: An Old Measure That Is Still Missing the Mark*

Critical Care Medicine. 52(3):498-501, March 2024.

Metabolic Syndrome and Acute Respiratory Distress Syndrome Outcomes: A Most Ingenious Paradox or a Devil in the Details?*

Critical Care Medicine. 52(3):502-505, March 2024.

Critical Care Medicine. 52(3):505-506, March 2024.

Eliminating Bias in Survival Estimation: Statistical Bias Mitigation Is the First Step Forward*

Critical Care Medicine. 52(3):506-509, March 2024.

Renin as a Prognostic and Predictive Biomarker in Sepsis: More Questions Than Answers?*

Critical Care Medicine. 52(3):509-512, March 2024.

Mechanical Left-Ventricular Unloading in Extracorporeal Cardiopulmonary Resuscitation: A State of Clinical Equipoise*

Critical Care Medicine. 52(3):512-515, March 2024.

Online Clinical Investigations
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Journal of Experimental Medicine
Journal of Experimental Medicine (JEM) publishes papers providing novel conceptual insight into immunology, neuroscience, cancer biology, vascular biology, microbial pathogenesis, and stem cell biology. Est. 1896 ... Brief Definitive Report | July 18 2024 SARS-CoV-2 brainstem encephalitis in human DBR1 deficiency ...
Journal of Experimental Medicine
Submission Guidelines | Journal of Experimental Medicine | Rockefeller University Press Submission Guidelines SUBMIT via our online manuscript submission system. If you need assistance, please contact the journal office at [email protected] or 212-327-8575. ... For Brief Definitive Reports, the Results and Discussion sections should be ...
Instructions for Authors
Journal of Experimental Medicine is a monthly, peer-reviewed journal that publishes both original research as well as reviews and commentary. Manuscripts should be submitted via our online manuscript submission system. Prior to submission, please familiarize yourself with our Editorial Policies and detailed instructions on how to prepare your ...
(PDF) Brief Definitive Report
The Journal of Experimental Medicine. on June 4, 2013 jem.rupress.org Downloaded from . ... Brief Definitive Report. Figure 2. Expressio n of IL28B and IP-10 mRNA re lies on TT/-G but not .
We are here for you and ready to hear from you
JEM Brief Definitive Reports would be an excellent format for short, solid studies. Recognizing that it will not be feasible for some time to do non-COVID-related experiments in many institutions, we will allow authors to add a section in the discussion regarding experiments requested by the reviewers that the authors cannot perform under the ...
Optimizing the JEM
Published since 1896, the Journal of Experimental Medicine was long ago established as a reliable source of high-impact findings relevant to human disease. Five months ago, ... Lastly, we have refocused our notion of what a JEM Brief Definitive Report should be. Rather than simply a shorter version of an Article, the BDR format will be reserved ...
Journal of Experimental Medicine
Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects.
Publishing with the JEM—Faster, Brighter, and More Accurate
With this change the online journal, rather than the printed journal, becomes the definitive version. Authors will now receive electronic figure proofs, and it is the accuracy of the online figures rather than the printed figures that will be assured. ... Articles from The Journal of Experimental Medicine are provided here courtesy of The ...
(PDF) Type I interferon signaling mediates Mycobacterium tuberculosis
Content available from Journal of Experimental Medicine (JEM) This content is subject to copyright. BRIEF DEFINITIVE REPORT. Type I interferon signaling mediates Mycobacterium.
Journal of Experimental Medicine
Aims and scope. Journal of Experimental Medicine (JEM) is a broad journal that publishes papers providing novel conceptual insight into immunology, cancer biology, vascular biology, microbial pathogenesis, neuroscience, and stem cell biology. We are interested in original findings on all aspects of disease pathogenesis, and we are happy to ...
PDF AUTHOR MINI-GUIDELINES FOR BRIEF DEFINITIVE REPORTS
clinical medicine, by publishing work that enhances our understanding of the pathophysiological mechanisms of human disease. Brief Definitive Reports provide a forum for the publication of highly significant and timely advances that convey a specific key message with definitive supporting evidence and have immediate impact .
PDF The Journal of Experimental Medicine
BRIEF DEFINITIVE REPORT that complete ablation of recipient APCs might abolish graft versus leukemia (GVL) eff ects (27), but a selective benefi t might be gained by regional therapy of a GVHD target organ such as the skin. LC recovery and the effect of GVHD During recovery, LC density declined to a similar nadir dur-
The Journal of Experimental Medicine
BRIEF DEFINITIVE REPORT the WT allele could not be detected in Ly3, indicating its deletion. Dual-color fl uorescence in situ hybridization (FISH) analysis confi rmed the loss of one copy of the BLIMP1 locus in this tetraploid cell line (Fig. 1 C), whereas the remaining BLIMP1 signal maps to chromosome 6, suggesting that the
PDF The Journal of Experimental Medicine
BRIEF DEFINITIVE REPORT in the virus life cycle before massive replication. An early in-crease of APOBEC3G by IFN-α likely promotes enhanced APOBEC3G packaging into the initial viral particles, which in turn renders these virions defective in establishing new rounds of infection. IFN uniquely regulates APOBEC3G
PDF The Journal of Experimental Medicine
BRIEF DEFINITIVE REPORT in an ATM-dependent manner that, for the fi rst time, dem-onstrates an active cross talk between ATM and ATR in the DNA damage response. Finally, the development of a new fl ow cytometry-based detection assay for DNA damage signaling events has allowed us to discover that IR-induced
Guidelines
Guidelines - Brief Report. Brief reports are similar to original research in that they follow the same rigor, format and guidelines, but are designed for small-scale research or research that is in early stages of development. These may include preliminary studies that utilize a simple research design or a small sample size and that have ...
Archive of "The Journal of Experimental Medicine".
Learn More Try it out now. Articles from this journal are generally available in PMC after a 6-month delay (embargo); however, the delay may vary at the discretion of the publisher. The Journal of Experimental Medicine Vols. 1 to 221; 1896 to 2024. National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894.
Volume 221 Issue 3
This study illuminates that TRPV2 augments B cell activation and function through membrane depolarization and cytoskeletal remodeling. Consequently, TRPV2 is implicated in antibody responses and SLE. The study underscores the indispensable role of TRPV2 in immune regulation and potential therapeutic interventions. View Article.
The Tohoku Journal of Experimental Medicine
The Tohoku Journal of Experimental Medicine. The Tohoku Journal of Experimental Medicine. Published by Tohoku University Medical Press. 11,312 registered articles (updated on June 06, 2023) Online ISSN : 1349-3329 Print ISSN : 0040-8727 ISSN-L : 0040-8727. Journal home.
The Tohoku Journal of Experimental Medicine
The Tohoku Journal of Experimental Medicine. Published by Tohoku University Medical Press 11,323 registered articles (updated on July 05, 2023) Online ISSN : 1349-3329 Print ISSN : 0040-8727 ISSN-L : 0040-8727 2.200 2022 Journal Impact Factor (JIF) JOURNAL PEER REVIEWED OPEN ACCESS FULL ...
The Tohoku Journal of Experimental Medicine
The GNRI was calculated using two different IBW methods: the LF and a BMI of 22 kg/m 2. We categorized GNRI results based on the original criteria or quartile criteria. Mortality outcomes were analyzed using the GNRI based on IBW (LF or BMI) and its classification (original criteria or quartile) through Cox proportional hazard regression.
Volume 218 Issue 10
In this issue of JEM, Gschwend et al. reveal the indispensable role of alveolar epithelial cells type 2 in controlling the density of alveolar macrophages. This study highlights the intricate crosstalk that lung stroma and macrophages undergo to maintain homeostasis. View Article.
Long COVID Is Not a Functional Neurologic Disorder
Long COVID is a common sequela of SARS-CoV-2 infection. Data from numerous scientific studies indicate that long COVID involves a complex interaction between pathophysiological processes. Long COVID may involve the development of new diagnosable health conditions and exacerbation of pre-existing health conditions. However, despite this rapidly accumulating body of evidence regarding the ...
March 2024
Read Online: Critical Care Medicine | Society of Critical Care Medicine Critical Care Medicine is the premier peer-reviewed, scientific publication in critical care medicine. Learn more about the journal and subscribe today! Editor-in-Chief: Timothy G. Buchman, PhD, MD, MCCM. ... Brief Report A Transcriptomic Classifier Model Identifies High ...
2021: The Year in Experimental Medicine
This year marked the 125 th anniversary of the Journal of Experimental Medicine ( JEM ). Since its inception in 1896, JEM has been a leader in publishing outstanding and enduring studies in medical biology and has greatly contributed to the fields of immunology, cancer biology, neuroscience, cardiovascular biology, host-pathogen interaction ...